{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","description":"This cluster of papers focuses on the mechanisms and regulation of apoptotic cell clearance, including the role of CD47, phagocytosis, TAM receptors, efferocytosis, and the implications for cancer immunotherapy. It explores the involvement of various molecules and pathways in the recognition and removal of apoptotic cells by phagocytes, shedding light on potential therapeutic targets for immune-related diseases.","keywords":[{"id":"https://openalex.org/keywords/efferocytosis","display_name":"efferocytosis","score":0.4087},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.3573},{"id":"https://openalex.org/keywords/sirpalpha","display_name":"SIRP\u03b1","score":0.4688},{"id":"https://openalex.org/keywords/apoptotic-cells","display_name":"apoptotic cells","score":0.2682},{"id":"https://openalex.org/keywords/mertk","display_name":"MERTK","score":0.2027},{"id":"https://openalex.org/keywords/anti-cd47-antibody","display_name":"anti-CD47 antibody","score":0.5954},{"id":"https://openalex.org/keywords/cd47-blockade","display_name":"CD47 blockade","score":0.4819},{"id":"https://openalex.org/keywords/phagocytosis-of-apoptotic-cells","display_name":"phagocytosis of apoptotic cells","score":0.3996},{"id":"https://openalex.org/keywords/tam-receptors","display_name":"TAM receptors","score":0.2413},{"id":"https://openalex.org/keywords/eat-me-signals","display_name":"eat-me signals","score":0.5976},{"id":"https://openalex.org/keywords/apoptotic-neutrophils","display_name":"apoptotic neutrophils","score":0.5199},{"id":"https://openalex.org/keywords/don-t-eat-me-signal","display_name":"don't eat me signal","score":0.6013},{"id":"https://openalex.org/keywords/phosphatidylserine-receptor","display_name":"phosphatidylserine receptor","score":0.4358},{"id":"https://openalex.org/keywords/innate-immune-checkpoint","display_name":"innate immune checkpoint","score":0.4677},{"id":"https://openalex.org/keywords/phagocytic-receptors","display_name":"phagocytic receptors","score":0.3484},{"id":"https://openalex.org/keywords/cd47-sirpalpha-axis","display_name":"CD47-SIRP\u03b1 axis","score":0.6463},{"id":"https://openalex.org/keywords/macrophage-efferocytosis","display_name":"macrophage efferocytosis","score":0.3252},{"id":"https://openalex.org/keywords/phagosome-formation","display_name":"phagosome formation","score":0.2036},{"id":"https://openalex.org/keywords/apoptotic-cell-recognition","display_name":"apoptotic cell recognition","score":0.5315},{"id":"https://openalex.org/keywords/apoptotic-cell-engulfment","display_name":"apoptotic cell engulfment","score":0.53},{"id":"https://openalex.org/keywords/neutrophil-clearance","display_name":"neutrophil clearance","score":0.216},{"id":"https://openalex.org/keywords/anti-cd47-monoclonal-antibody","display_name":"anti-CD47 monoclonal antibody","score":0.5634},{"id":"https://openalex.org/keywords/cd47-sirpalpha-interaction","display_name":"CD47-SIRP\u03b1 interaction","score":0.7169},{"id":"https://openalex.org/keywords/tumor-phagocytosis","display_name":"tumor phagocytosis","score":0.4335},{"id":"https://openalex.org/keywords/find-me-signals","display_name":"find-me signals","score":0.5975}],"legacy_keywords":"CD47; apoptotic cells; phagocytosis; immune regulation; clearance mechanisms; TAM receptors; efferocytosis; cancer immunotherapy; phosphatidylserine; macrophages","ids":{"openalex":"https://openalex.org/T12672","wikipedia":"https://en.wikipedia.org/wiki/Apoptotic_cell_clearance"},"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology"},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation"},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis"},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota"},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses"},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases"},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction"},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer"},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine"},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms"},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy"},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms"},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses"},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders"},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies"},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods"},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology"},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins"},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways"},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases"},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor"},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations"},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses"},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways"},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms"}],"works_count":16629,"cited_by_count":470573,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12672","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:15"}