{"id":"https://openalex.org/T12653","display_name":"Cyclization and Aryne Chemistry","description":"This cluster of papers explores the advances in aryne chemistry and its applications in organic synthesis, including transition-metal-free reactions, natural product total synthesis, multicomponent coupling, and the use of arynes in Diels\u2013Alder reactions. The research also delves into the synthesis of heterocycles, regioselectivities of aryne reactions, and the role of arynes in the construction of polycyclic aromatic compounds.","keywords":[{"id":"https://openalex.org/keywords/benzyne","display_name":"benzyne","score":0.6008},{"id":"https://openalex.org/keywords/arynes","display_name":"arynes","score":0.7145},{"id":"https://openalex.org/keywords/enediynes","display_name":"enediynes","score":0.3177},{"id":"https://openalex.org/keywords/anthracyclinones","display_name":"anthracyclinones","score":0.5736},{"id":"https://openalex.org/keywords/cycloaromatization","display_name":"cycloaromatization","score":0.3684},{"id":"https://openalex.org/keywords/bergman-cyclization","display_name":"Bergman cyclization","score":0.4022},{"id":"https://openalex.org/keywords/aryne-intermediates","display_name":"aryne intermediates","score":0.6151},{"id":"https://openalex.org/keywords/aryne-chemistry","display_name":"aryne chemistry","score":0.8328},{"id":"https://openalex.org/keywords/aryne-synthesis","display_name":"aryne synthesis","score":0.3178},{"id":"https://openalex.org/keywords/aryne-precursors","display_name":"aryne precursors","score":0.7805},{"id":"https://openalex.org/keywords/enediyne-antibiotics","display_name":"enediyne antibiotics","score":0.2907},{"id":"https://openalex.org/keywords/hexadehydro-diels-alder-reaction","display_name":"hexadehydro-Diels-Alder reaction","score":0.7306},{"id":"https://openalex.org/keywords/aryne-insertion","display_name":"aryne insertion","score":0.9027},{"id":"https://openalex.org/keywords/benzyne-intermediates","display_name":"benzyne intermediates","score":0.376},{"id":"https://openalex.org/keywords/benzyne-precursors","display_name":"benzyne precursors","score":0.7493},{"id":"https://openalex.org/keywords/daunomycinone","display_name":"daunomycinone","score":0.2446},{"id":"https://openalex.org/keywords/dehydrobenzene","display_name":"dehydrobenzene","score":0.2348},{"id":"https://openalex.org/keywords/enyne-allenes","display_name":"enyne-allenes","score":0.5431},{"id":"https://openalex.org/keywords/dynemicin-a","display_name":"dynemicin A","score":0.3625},{"id":"https://openalex.org/keywords/anthracycline-synthesis","display_name":"anthracycline synthesis","score":0.4929},{"id":"https://openalex.org/keywords/enediyne-synthesis","display_name":"enediyne synthesis","score":0.3704},{"id":"https://openalex.org/keywords/esperamicin","display_name":"esperamicin","score":0.2833},{"id":"https://openalex.org/keywords/neocarzinostatin-chromophore","display_name":"neocarzinostatin chromophore","score":0.294},{"id":"https://openalex.org/keywords/kedarcidin","display_name":"kedarcidin","score":0.2774}],"legacy_keywords":"Arynes; Organic Synthesis; Transition-Metal-Free Reactions; Natural Product Total Synthesis; Multicomponent Coupling; Diels\u2013Alder Reactions; Benzynes; Heterocycles; Regioselectivities; Polycyclic Aromatic Compounds","ids":{"openalex":"https://openalex.org/T12653","wikipedia":"https://en.wikipedia.org/wiki/Aryne_chemistry"},"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"},"siblings":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis"},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis"},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity"},{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods"},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization"},{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions"},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes"},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions"},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems"},{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles"},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis"},{"id":"https://openalex.org/T10871","display_name":"Catalytic Alkyne Reactions"},{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis"},{"id":"https://openalex.org/T10956","display_name":"Fullerene Chemistry and Applications"},{"id":"https://openalex.org/T11298","display_name":"Synthesis and Properties of Aromatic Compounds"},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications"},{"id":"https://openalex.org/T11441","display_name":"Organoboron and organosilicon chemistry"},{"id":"https://openalex.org/T11549","display_name":"Synthetic Organic Chemistry Methods"},{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms"},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry"},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis"},{"id":"https://openalex.org/T11790","display_name":"N-Heterocyclic Carbenes in Organic and Inorganic Chemistry"},{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions"},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions"},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques"},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms"},{"id":"https://openalex.org/T12228","display_name":"Coordination Chemistry and Organometallics"},{"id":"https://openalex.org/T12240","display_name":"Nanomaterials for catalytic reactions"},{"id":"https://openalex.org/T12251","display_name":"Synthesis and Catalytic Reactions"},{"id":"https://openalex.org/T12270","display_name":"Microwave-Assisted Synthesis and Applications"},{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications"},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds"},{"id":"https://openalex.org/T12458","display_name":"Organometallic Compounds Synthesis and Characterization"},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications"},{"id":"https://openalex.org/T12527","display_name":"Chemistry and Stereochemistry Studies"},{"id":"https://openalex.org/T12562","display_name":"Synthesis and Characterization of Pyrroles"},{"id":"https://openalex.org/T12570","display_name":"Photopolymerization techniques and applications"},{"id":"https://openalex.org/T12852","display_name":"Chemical Thermodynamics and Molecular Structure"},{"id":"https://openalex.org/T12893","display_name":"Organic Chemistry Cycloaddition Reactions"},{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives"},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants"},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives"},{"id":"https://openalex.org/T13115","display_name":"Axial and Atropisomeric Chirality Synthesis"},{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids"},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation"},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds"},{"id":"https://openalex.org/T13230","display_name":"Synthesis and Reactivity of Heterocycles"},{"id":"https://openalex.org/T13239","display_name":"Phosphorus compounds and reactions"},{"id":"https://openalex.org/T13265","display_name":"Synthesis of Tetrazole Derivatives"},{"id":"https://openalex.org/T13304","display_name":"Synthesis and Reactivity of Sulfur-Containing Compounds"},{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds"},{"id":"https://openalex.org/T13568","display_name":"Wood and Agarwood Research"},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry"},{"id":"https://openalex.org/T13833","display_name":"Ferrocene Chemistry and Applications"},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods"},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies"},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds"},{"id":"https://openalex.org/T14297","display_name":"Plant-Derived Bioactive Compounds"},{"id":"https://openalex.org/T14318","display_name":"Polydiacetylene-based materials and applications"},{"id":"https://openalex.org/T14459","display_name":"Synthesis and Reactions of Organic Compounds"}],"works_count":9665,"cited_by_count":144077,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12653","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:15"}