{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","description":"This cluster of papers focuses on the development and efficacy of immunotoxin therapy for cancer treatment, with a particular emphasis on ricin poisoning, ribosome-inactivating proteins, and targeted therapy using recombinant immunotoxins. It also explores the use of IL-13 receptor and mistletoe extract in cancer therapy.","keywords":[{"id":"https://openalex.org/keywords/immunotoxins","display_name":"immunotoxins","score":0.6385},{"id":"https://openalex.org/keywords/ricin","display_name":"ricin","score":0.6101},{"id":"https://openalex.org/keywords/ribosome-inactivating-proteins","display_name":"ribosome-inactivating proteins","score":0.6699},{"id":"https://openalex.org/keywords/ricin-a-chain","display_name":"ricin A chain","score":0.8689},{"id":"https://openalex.org/keywords/pseudomonas-exotoxin-a","display_name":"Pseudomonas exotoxin A","score":0.6841},{"id":"https://openalex.org/keywords/viscum-album","display_name":"Viscum album","score":0.2251},{"id":"https://openalex.org/keywords/ricin-toxin","display_name":"ricin toxin","score":0.7675},{"id":"https://openalex.org/keywords/abrin","display_name":"abrin","score":0.6068},{"id":"https://openalex.org/keywords/mistletoe-extract","display_name":"mistletoe extract","score":0.3502},{"id":"https://openalex.org/keywords/recombinant-immunotoxin","display_name":"recombinant immunotoxin","score":0.8317},{"id":"https://openalex.org/keywords/pseudomonas-exotoxin","display_name":"Pseudomonas exotoxin","score":0.7216},{"id":"https://openalex.org/keywords/ricin-b-chain","display_name":"ricin B chain","score":0.8289},{"id":"https://openalex.org/keywords/trichosanthin","display_name":"trichosanthin","score":0.4914},{"id":"https://openalex.org/keywords/saporin","display_name":"saporin","score":0.4659},{"id":"https://openalex.org/keywords/gelonin","display_name":"gelonin","score":0.7476},{"id":"https://openalex.org/keywords/mistletoe-lectin","display_name":"mistletoe lectin","score":0.6249},{"id":"https://openalex.org/keywords/ribosome-inactivation","display_name":"ribosome inactivation","score":0.451},{"id":"https://openalex.org/keywords/toxin-mechanism-of-action","display_name":"toxin mechanism of action","score":0.2142},{"id":"https://openalex.org/keywords/toxin-internalization","display_name":"toxin internalization","score":0.2799},{"id":"https://openalex.org/keywords/protein-toxins","display_name":"protein toxins","score":0.2172},{"id":"https://openalex.org/keywords/pokeweed-antiviral-protein","display_name":"pokeweed antiviral protein","score":0.6193},{"id":"https://openalex.org/keywords/exotoxin-a","display_name":"exotoxin A","score":0.2526},{"id":"https://openalex.org/keywords/chimeric-toxin","display_name":"chimeric toxin","score":0.6021},{"id":"https://openalex.org/keywords/ricin-toxicity","display_name":"ricin toxicity","score":0.6954},{"id":"https://openalex.org/keywords/onconase","display_name":"onconase","score":0.5256}],"legacy_keywords":"Immunotoxin; Ricin Poisoning; Ribosome-Inactivating Proteins; Cancer Therapy; Diphtheria Toxin; Targeted Therapy; Recombinant Immunotoxin; IL-13 Receptor; Ricinus communis; Mistletoe Extract","ids":{"openalex":"https://openalex.org/T12477","wikipedia":"https://en.wikipedia.org/wiki/Immunotoxin_therapy"},"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology"},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation"},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis"},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota"},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses"},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases"},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction"},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer"},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine"},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms"},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy"},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms"},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses"},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders"},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies"},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods"},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology"},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways"},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation"},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases"},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor"},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations"},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses"},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways"},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms"}],"works_count":19411,"cited_by_count":341639,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12477","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:14"}