{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","description":"This cluster of papers explores the role of lipid metabolism, including fatty acid synthesis, cholesterol metabolism, and statin use, in the pathogenesis and progression of cancer. It discusses the metabolic reprogramming of cancer cells, the impact of specific enzymes and receptors such as Fatty Acid Synthase and CD36, and the potential therapeutic implications of targeting lipid metabolism in cancer treatment.","keywords":[{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.209},{"id":"https://openalex.org/keywords/lipid-metabolic-reprogramming","display_name":"lipid metabolism reprogramming","score":0.4655},{"id":"https://openalex.org/keywords/fasn-inhibition","display_name":"FASN inhibition","score":0.8119},{"id":"https://openalex.org/keywords/fasn-inhibitors","display_name":"FASN inhibitors","score":0.7917},{"id":"https://openalex.org/keywords/fatty-acid-synthase-inhibition","display_name":"fatty acid synthase inhibition","score":0.3665},{"id":"https://openalex.org/keywords/acss2","display_name":"ACSS2","score":0.3324},{"id":"https://openalex.org/keywords/choline-kinase-alpha","display_name":"choline kinase alpha","score":0.5042},{"id":"https://openalex.org/keywords/fatty-acid-synthase-inhibitors","display_name":"fatty acid synthase inhibitors","score":0.3923},{"id":"https://openalex.org/keywords/tumor-lipid-metabolism","display_name":"tumor lipid metabolism","score":0.5757},{"id":"https://openalex.org/keywords/c75","display_name":"C75","score":0.4021},{"id":"https://openalex.org/keywords/lipophilic-statins","display_name":"lipophilic statins","score":0.3111},{"id":"https://openalex.org/keywords/tumor-lipids","display_name":"tumor lipids","score":0.6142},{"id":"https://openalex.org/keywords/acsm3","display_name":"ACSM3","score":0.6208},{"id":"https://openalex.org/keywords/acsm1","display_name":"ACSM1","score":0.7362},{"id":"https://openalex.org/keywords/scd1-inhibition","display_name":"SCD1 inhibition","score":0.5487},{"id":"https://openalex.org/keywords/lipid-metabolism-in-cancer","display_name":"lipid metabolism in cancer","score":0.654},{"id":"https://openalex.org/keywords/hydrophilic-statins","display_name":"hydrophilic statins","score":0.2994},{"id":"https://openalex.org/keywords/soat1","display_name":"SOAT1","score":0.2064},{"id":"https://openalex.org/keywords/acsl5","display_name":"ACSL5","score":0.2821},{"id":"https://openalex.org/keywords/cancer-associated-adipocytes","display_name":"cancer-associated adipocytes","score":0.2207},{"id":"https://openalex.org/keywords/fatostatin","display_name":"fatostatin","score":0.3864},{"id":"https://openalex.org/keywords/scd1-inhibitors","display_name":"SCD1 inhibitors","score":0.4022},{"id":"https://openalex.org/keywords/tvb-2640","display_name":"TVB-2640","score":0.3905},{"id":"https://openalex.org/keywords/acetyl-coa-synthetase-2","display_name":"acetyl-CoA synthetase 2","score":0.3421},{"id":"https://openalex.org/keywords/long-term-statin-use","display_name":"long-term statin use","score":0.3097}],"legacy_keywords":"Lipid Metabolism; Fatty Acid Synthase; Cholesterol; Statins; Cancer; Metabolic Reprogramming; Lipogenesis; CD36 Receptor; HMG-CoA Reductase Inhibitors; Acetyl-CoA Carboxylase","ids":{"openalex":"https://openalex.org/T12465","wikipedia":"https://en.wikipedia.org/wiki/Lipid_metabolism"},"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation"},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies"},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment"},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research"},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms"},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism"},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics"},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies"},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways"},{"id":"https://openalex.org/T13350","display_name":"Myxozoan Parasites in Aquatic Species"},{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies"},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity"}],"works_count":29412,"cited_by_count":620172,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12465","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:14"}