{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","description":"This cluster of papers focuses on the diagnosis and management of adrenal insufficiency, particularly in the context of septic shock and autoimmune polyendocrine syndrome. It covers topics such as corticosteroid therapy, hydrocortisone treatment, AIRE gene mutations, cortisol response, and the impact on the hypothalamic-pituitary-adrenal axis. The research also delves into glucocorticoid replacement, autoimmune disorders, and endocrine dysfunction.","keywords":[{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.5169},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.2094},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.3969},{"id":"https://openalex.org/keywords/addison-s-disease","display_name":"Addison's disease","score":0.6833},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.5098},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.207},{"id":"https://openalex.org/keywords/adrenal-crisis","display_name":"adrenal crisis","score":0.6967},{"id":"https://openalex.org/keywords/adrenal-function","display_name":"adrenal function","score":0.4733},{"id":"https://openalex.org/keywords/adrenocortical-function","display_name":"adrenocortical function","score":0.477},{"id":"https://openalex.org/keywords/adrenocortical-hormones","display_name":"adrenal cortex hormones","score":0.3716},{"id":"https://openalex.org/keywords/secondary-adrenal-insufficiency","display_name":"secondary adrenal insufficiency","score":0.6451},{"id":"https://openalex.org/keywords/adrenal-hormones","display_name":"adrenal hormones","score":0.3229},{"id":"https://openalex.org/keywords/glucocorticoid-replacement-therapy","display_name":"glucocorticoid replacement therapy","score":0.5583},{"id":"https://openalex.org/keywords/17-ketosteroids","display_name":"17-ketosteroids","score":0.2947},{"id":"https://openalex.org/keywords/adrenal-function-testing","display_name":"adrenal function testing","score":0.6559},{"id":"https://openalex.org/keywords/pituitary-adrenal-axis","display_name":"pituitary-adrenal axis","score":0.2558},{"id":"https://openalex.org/keywords/adrenal-suppression","display_name":"adrenal suppression","score":0.4922},{"id":"https://openalex.org/keywords/adrenal-diseases","display_name":"adrenal disorders","score":0.3413},{"id":"https://openalex.org/keywords/adrenal-steroidogenesis","display_name":"adrenal steroidogenesis","score":0.3636},{"id":"https://openalex.org/keywords/mineralocorticoids","display_name":"mineralocorticoids","score":0.2345},{"id":"https://openalex.org/keywords/acth-secretion","display_name":"ACTH secretion","score":0.2101},{"id":"https://openalex.org/keywords/deoxycorticosterone","display_name":"deoxycorticosterone","score":0.213},{"id":"https://openalex.org/keywords/17-hydroxycorticosteroids","display_name":"17-hydroxycorticosteroids","score":0.4499},{"id":"https://openalex.org/keywords/adrenal-hemorrhage","display_name":"adrenal hemorrhage","score":0.33},{"id":"https://openalex.org/keywords/acth-deficiency","display_name":"ACTH deficiency","score":0.3772}],"legacy_keywords":"Adrenal Insufficiency; Corticosteroid Therapy; Septic Shock; Autoimmune Polyendocrine Syndrome; Hydrocortisone Treatment; Glucocorticoid Replacement; AIRE Gene Mutations; Cortisol Response; Endocrine Disorders; Hypothalamic-Pituitary-Adrenal Axis Dysfunction","ids":{"openalex":"https://openalex.org/T12421","wikipedia":"https://en.wikipedia.org/wiki/Adrenal_insufficiency"},"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins"},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments"},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management"},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research"},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments"},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors"},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education"},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments"},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies"},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies"},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management"},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients"},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension"},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease"},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies"},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders"}],"works_count":91845,"cited_by_count":889806,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12421","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:14"}