{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","description":"This cluster of papers explores the role of quinones in toxicology and pharmacology, focusing on their cytotoxic effects, NAD(P)H:Quinone Oxidoreductase activity, apoptosis induction, and potential as anticancer and antimicrobial agents. The papers cover a wide range of topics including cellular pharmacology studies, mechanisms of cytotoxic action, pharmacological properties, and the synthesis and evaluation of quinone derivatives.","keywords":[{"id":"https://openalex.org/keywords/naphthoquinones","display_name":"naphthoquinones","score":0.2375},{"id":"https://openalex.org/keywords/1-4-naphthoquinone","display_name":"1,4-naphthoquinone","score":0.2047},{"id":"https://openalex.org/keywords/beta-lapachone","display_name":"\u03b2-lapachone","score":0.365},{"id":"https://openalex.org/keywords/dt-diaphorase","display_name":"DT-diaphorase","score":0.3592},{"id":"https://openalex.org/keywords/lapachol","display_name":"lapachol","score":0.2931},{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase-1","display_name":"NAD(P)H:quinone oxidoreductase 1","score":0.2488},{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase","display_name":"NAD(P)H:quinone oxidoreductase","score":0.319},{"id":"https://openalex.org/keywords/1-4-naphthoquinone-derivatives","display_name":"1,4-naphthoquinone derivatives","score":0.4411},{"id":"https://openalex.org/keywords/naphthoquinone-synthesis","display_name":"naphthoquinone synthesis","score":0.3058},{"id":"https://openalex.org/keywords/quinone-chemistry","display_name":"quinone chemistry","score":0.2015},{"id":"https://openalex.org/keywords/shikonin-derivatives","display_name":"shikonin derivatives","score":0.3447},{"id":"https://openalex.org/keywords/bioreductive-activation","display_name":"bioreductive activation","score":0.4515},{"id":"https://openalex.org/keywords/quinone-toxicity","display_name":"quinone toxicity","score":0.4389},{"id":"https://openalex.org/keywords/nqo2","display_name":"NQO2","score":0.2796},{"id":"https://openalex.org/keywords/bioreductive-drugs","display_name":"bioreductive drugs","score":0.2684},{"id":"https://openalex.org/keywords/bioreductive-alkylating-agents","display_name":"bioreductive alkylating agents","score":0.5831},{"id":"https://openalex.org/keywords/quinone-metabolism","display_name":"quinone metabolism","score":0.3862},{"id":"https://openalex.org/keywords/alpha-lapachone","display_name":"\u03b1-lapachone","score":0.5034},{"id":"https://openalex.org/keywords/indolequinones","display_name":"indolequinones","score":0.353},{"id":"https://openalex.org/keywords/eo9","display_name":"EO9","score":0.579},{"id":"https://openalex.org/keywords/acetylshikonin","display_name":"acetylshikonin","score":0.2384},{"id":"https://openalex.org/keywords/quinone-detoxification","display_name":"quinone detoxification","score":0.4296},{"id":"https://openalex.org/keywords/quinone-reductase-2","display_name":"quinone reductase 2","score":0.2471},{"id":"https://openalex.org/keywords/diaziquone","display_name":"diaziquone","score":0.2804},{"id":"https://openalex.org/keywords/nqo1-inhibitors","display_name":"NQO1 inhibitors","score":0.4647}],"legacy_keywords":"Quinones; Toxicology; Pharmacology; Cytotoxicity; NAD(P)H:Quinone Oxidoreductase; Apoptosis; Anticancer Agents; Reactive Oxygen Species; Antimicrobial Activity; Cell Signaling","ids":{"openalex":"https://openalex.org/T12356","wikipedia":"https://en.wikipedia.org/wiki/Quinone_toxicity"},"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis"},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry"},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions"}],"works_count":24727,"cited_by_count":372786,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12356","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:14"}