{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","description":"This cluster of papers focuses on the immunogenicity of biosimilar therapeutics, including the validation of bioanalytical methods for assessing immunogenicity, the impact of manufacturing changes on immunogenicity, and the clinical outcomes and safety of switching from reference biologics to biosimilars. The use of dried blood spots for bioanalysis and the regulatory considerations for biosimilars are also prominent topics within this cluster.","keywords":[{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.587},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.2008},{"id":"https://openalex.org/keywords/biologic-drugs","display_name":"biologic drugs","score":0.3947},{"id":"https://openalex.org/keywords/biosimilar-approval","display_name":"biosimilar approval","score":0.9079},{"id":"https://openalex.org/keywords/biosimilar-switching","display_name":"biosimilar switching","score":0.7661},{"id":"https://openalex.org/keywords/biosimilar-infliximab","display_name":"infliximab biosimilar","score":0.5003},{"id":"https://openalex.org/keywords/biosimilarity","display_name":"biosimilarity","score":0.7484},{"id":"https://openalex.org/keywords/ct-p13","display_name":"CT-P13","score":0.534},{"id":"https://openalex.org/keywords/adalimumab-biosimilar","display_name":"adalimumab biosimilar","score":0.6238},{"id":"https://openalex.org/keywords/biological-drugs","display_name":"biological drugs","score":0.2183},{"id":"https://openalex.org/keywords/biosimilar-development","display_name":"biosimilar development","score":0.8333},{"id":"https://openalex.org/keywords/ligand-binding-assays","display_name":"ligand binding assay","score":0.2856},{"id":"https://openalex.org/keywords/antidrug-antibodies","display_name":"antidrug antibodies","score":0.2542},{"id":"https://openalex.org/keywords/biosimilar-interchangeability","display_name":"biosimilar interchangeability","score":0.7859},{"id":"https://openalex.org/keywords/biosimilar-uptake","display_name":"biosimilar uptake","score":0.7555},{"id":"https://openalex.org/keywords/biosimilar-insulin","display_name":"biosimilar insulin","score":0.6345},{"id":"https://openalex.org/keywords/biosimilarity-assessment","display_name":"biosimilarity assessment","score":0.9007},{"id":"https://openalex.org/keywords/biosimilar-adoption","display_name":"biosimilar adoption","score":0.7911},{"id":"https://openalex.org/keywords/biosimilar-regulation","display_name":"biosimilar regulation","score":0.8954},{"id":"https://openalex.org/keywords/biosimilar-safety","display_name":"biosimilar safety","score":0.8099},{"id":"https://openalex.org/keywords/biological-medicines","display_name":"biological medicines","score":0.3137},{"id":"https://openalex.org/keywords/reference-products","display_name":"reference products","score":0.5114},{"id":"https://openalex.org/keywords/biosimilar-substitution","display_name":"biosimilar substitution","score":0.7491},{"id":"https://openalex.org/keywords/trastuzumab-biosimilar","display_name":"trastuzumab biosimilar","score":0.3997},{"id":"https://openalex.org/keywords/rituximab-biosimilar","display_name":"rituximab biosimilar","score":0.4667}],"legacy_keywords":"Biosimilars; Immunogenicity; Bioanalytical Methods; Therapeutic Proteins; Dried Blood Spots; Erythropoietin Antibodies; Monoclonal Antibodies; Regulatory Guidelines; Biopharmaceuticals; Clinical Outcomes","ids":{"openalex":"https://openalex.org/T12255","wikipedia":"https://en.wikipedia.org/wiki/Biosimilar"},"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology"},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation"},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis"},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota"},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses"},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases"},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction"},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer"},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine"},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms"},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy"},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms"},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses"},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders"},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies"},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology"},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins"},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways"},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation"},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases"},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor"},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations"},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses"},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways"},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms"}],"works_count":19946,"cited_by_count":212717,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12255","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:13"}