{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","description":"This cluster of papers explores the multifaceted role of osteopontin in biomineralization, inflammation, immune regulation, cancer progression, and cell signaling. It delves into its influence on various conditions such as dentinogenesis imperfecta, tumor metastasis, and autoimmune demyelinating disease. The papers also discuss the involvement of matricellular proteins in modulating cell function and tissue response to injury.","keywords":[{"id":"https://openalex.org/keywords/bone-sialoprotein","display_name":"bone sialoprotein","score":0.2031},{"id":"https://openalex.org/keywords/amelogenin","display_name":"amelogenin","score":0.2152},{"id":"https://openalex.org/keywords/enamel-matrix-proteins","display_name":"enamel matrix proteins","score":0.2727},{"id":"https://openalex.org/keywords/enamel-matrix","display_name":"enamel matrix","score":0.3375},{"id":"https://openalex.org/keywords/enamel-mineralization","display_name":"enamel mineralization","score":0.2003},{"id":"https://openalex.org/keywords/dentin-mineralization","display_name":"dentin mineralization","score":0.2742},{"id":"https://openalex.org/keywords/dentin-sialophosphoprotein","display_name":"dentin sialophosphoprotein","score":0.23},{"id":"https://openalex.org/keywords/bone-matrix-proteins","display_name":"bone matrix proteins","score":0.3066},{"id":"https://openalex.org/keywords/non-collagenous-proteins","display_name":"non-collagenous proteins","score":0.2018},{"id":"https://openalex.org/keywords/dentin-matrix","display_name":"dentin matrix","score":0.285},{"id":"https://openalex.org/keywords/enamel-proteins","display_name":"enamel proteins","score":0.4486},{"id":"https://openalex.org/keywords/dentin-matrix-proteins","display_name":"dentin matrix proteins","score":0.2995},{"id":"https://openalex.org/keywords/predentin","display_name":"predentin","score":0.2723},{"id":"https://openalex.org/keywords/dentin-sialoprotein","display_name":"dentin sialoprotein","score":0.3399},{"id":"https://openalex.org/keywords/enamel-maturation","display_name":"enamel maturation","score":0.2146},{"id":"https://openalex.org/keywords/dentin-phosphoprotein","display_name":"dentin phosphoprotein","score":0.7013},{"id":"https://openalex.org/keywords/ameloblastin","display_name":"ameloblastin","score":0.242},{"id":"https://openalex.org/keywords/enamelin","display_name":"enamelin","score":0.3115},{"id":"https://openalex.org/keywords/secreted-protein-acidic-and-rich-in-cysteine","display_name":"secreted protein acidic and rich in cysteine","score":0.299},{"id":"https://openalex.org/keywords/enamel-biomineralization","display_name":"enamel biomineralization","score":0.4447},{"id":"https://openalex.org/keywords/phosphophoryn","display_name":"phosphophoryn","score":0.6883},{"id":"https://openalex.org/keywords/dentinogenesis-imperfecta-type-ii","display_name":"dentinogenesis imperfecta type II","score":0.4377},{"id":"https://openalex.org/keywords/sibling-proteins","display_name":"SIBLING proteins","score":0.5832},{"id":"https://openalex.org/keywords/hereditary-dentin-disorders","display_name":"hereditary dentin disorders","score":0.3293},{"id":"https://openalex.org/keywords/dentin-dysplasia","display_name":"dentin dysplasia","score":0.2238}],"legacy_keywords":"Osteopontin; Biomineralization; Inflammation; Matricellular Proteins; Cell Signaling; Cancer Progression; Immune Regulation; Tumor Metastasis; Dentinogenesis Imperfecta; Extracellular Modulators","ids":{"openalex":"https://openalex.org/T12110","wikipedia":"https://en.wikipedia.org/wiki/Osteopontin"},"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms"},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies"},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research"},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments"},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research"},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments"},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments"},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases"},{"id":"https://openalex.org/T11991","display_name":"Soft tissue tumor case studies"},{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions"},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes"},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus"},{"id":"https://openalex.org/T12747","display_name":"Moyamoya disease diagnosis and treatment"},{"id":"https://openalex.org/T12800","display_name":"Musculoskeletal synovial abnormalities and treatments"},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions"},{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions"},{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments"},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research"},{"id":"https://openalex.org/T13452","display_name":"GDF15 and Related Biomarkers"},{"id":"https://openalex.org/T13543","display_name":"Oropharyngeal Anatomy and Pathologies"},{"id":"https://openalex.org/T13962","display_name":"Omental and Epiploic Conditions"},{"id":"https://openalex.org/T14015","display_name":"Otitis Media and Relapsing Polychondritis"},{"id":"https://openalex.org/T14057","display_name":"Hypertrophic osteoarthropathy and related conditions"}],"works_count":12224,"cited_by_count":353444,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12110","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:13"}