{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","description":"This cluster of papers focuses on the function, regulation, and physiological impact of hemoglobin and related proteins in vertebrates. It covers topics such as scavenger receptor CD163 expression, neuroglobin and myoglobin function, haptoglobin phenotype, nitric oxide dioxygenase activity, and the role of flavohemoglobins in detoxifying nitric oxide. The papers also discuss the use of hemoglobin-based oxygen carriers and their potential impact on cardiovascular disease.","keywords":[{"id":"https://openalex.org/keywords/myoglobin","display_name":"myoglobin","score":0.2},{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.5854},{"id":"https://openalex.org/keywords/heme-proteins","display_name":"heme proteins","score":0.2823},{"id":"https://openalex.org/keywords/oxygen-binding","display_name":"oxygen binding","score":0.6035},{"id":"https://openalex.org/keywords/methemoglobin","display_name":"methemoglobin","score":0.2778},{"id":"https://openalex.org/keywords/bohr-effect","display_name":"Bohr effect","score":0.6598},{"id":"https://openalex.org/keywords/hemocyanin","display_name":"hemocyanin","score":0.3359},{"id":"https://openalex.org/keywords/human-hemoglobin","display_name":"human hemoglobin","score":0.6188},{"id":"https://openalex.org/keywords/co-binding","display_name":"carbon monoxide binding","score":0.4807},{"id":"https://openalex.org/keywords/blood-substitutes","display_name":"blood substitutes","score":0.2375},{"id":"https://openalex.org/keywords/2-3-bisphosphoglycerate","display_name":"2,3-diphosphoglycerate","score":0.2182},{"id":"https://openalex.org/keywords/hemoglobin-structure","display_name":"hemoglobin structure","score":0.5488},{"id":"https://openalex.org/keywords/oxyhemoglobin-dissociation-curve","display_name":"oxygen dissociation curve","score":0.4313},{"id":"https://openalex.org/keywords/hemoglobin-oxygen-affinity","display_name":"hemoglobin oxygen affinity","score":0.3633},{"id":"https://openalex.org/keywords/hemoglobin-based-oxygen-carriers","display_name":"hemoglobin-based oxygen carriers","score":0.4578},{"id":"https://openalex.org/keywords/p50","display_name":"P50","score":0.2389},{"id":"https://openalex.org/keywords/globin","display_name":"globin","score":0.4522},{"id":"https://openalex.org/keywords/hemoglobin-a","display_name":"hemoglobin A","score":0.2667},{"id":"https://openalex.org/keywords/neuroglobin","display_name":"neuroglobin","score":0.4873},{"id":"https://openalex.org/keywords/metmyoglobin","display_name":"metmyoglobin","score":0.2885},{"id":"https://openalex.org/keywords/sperm-whale-myoglobin","display_name":"sperm whale myoglobin","score":0.5532},{"id":"https://openalex.org/keywords/hemoglobin-oxidation","display_name":"hemoglobin oxidation","score":0.3396},{"id":"https://openalex.org/keywords/distal-histidine","display_name":"distal histidine","score":0.6714},{"id":"https://openalex.org/keywords/nitric-oxide-binding","display_name":"nitric oxide binding","score":0.447},{"id":"https://openalex.org/keywords/heme-protein-interaction","display_name":"heme-protein interaction","score":0.4493}],"legacy_keywords":"Hemoglobin; Scavenger Receptor; Globin Family; Oxygen Carriers; Neuroglobin; CD163 Expression; Myoglobin Function; Haptoglobin Phenotype; Nitric Oxide Dioxygenase; Flavohemoglobin","ids":{"openalex":"https://openalex.org/T12094","wikipedia":"https://en.wikipedia.org/wiki/Hemoglobin"},"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions"},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics"},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion"},{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases"},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research"},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation"},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease"},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition"},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research"},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications"},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ"},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine"},{"id":"https://openalex.org/T12712","display_name":"Myofascial pain diagnosis and treatment"},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes"},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies"},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation"}],"works_count":43329,"cited_by_count":829471,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12094","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:13"}