{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","description":"This cluster of papers focuses on Tuberous Sclerosis Complex (TSC) and related disorders, including Lymphangioleiomyomatosis and Angiomyolipoma. It covers various aspects such as genetic mutations, neurological manifestations, use of mTOR inhibitors, diagnostic criteria, and the role of hamartin and tuberin proteins. Additionally, it explores the association with epilepsy and cognitive impairment.","keywords":[{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":0.6886},{"id":"https://openalex.org/keywords/renal-angiomyolipoma","display_name":"renal angiomyolipoma","score":0.6698},{"id":"https://openalex.org/keywords/lymphangioleiomyomatosis","display_name":"lymphangioleiomyomatosis","score":0.724},{"id":"https://openalex.org/keywords/angiomyolipoma","display_name":"angiomyolipoma","score":0.4562},{"id":"https://openalex.org/keywords/tsc2","display_name":"TSC2","score":0.4072},{"id":"https://openalex.org/keywords/tsc1","display_name":"TSC1","score":0.4885},{"id":"https://openalex.org/keywords/birt-hogg-dube-syndrome","display_name":"Birt-Hogg-Dub\u00e9 syndrome","score":0.5219},{"id":"https://openalex.org/keywords/pulmonary-cysts","display_name":"pulmonary cysts","score":0.2309},{"id":"https://openalex.org/keywords/subependymal-giant-cell-astrocytoma","display_name":"subependymal giant cell astrocytoma","score":0.7782},{"id":"https://openalex.org/keywords/perivascular-epithelioid-cell-tumor","display_name":"PEComa","score":0.4081},{"id":"https://openalex.org/keywords/tsc2-gene","display_name":"TSC2 gene","score":0.8871},{"id":"https://openalex.org/keywords/cortical-tubers","display_name":"cortical tubers","score":0.8757},{"id":"https://openalex.org/keywords/pulmonary-lymphangioleiomyomatosis","display_name":"pulmonary lymphangioleiomyomatosis","score":0.8617},{"id":"https://openalex.org/keywords/tsc1-gene","display_name":"TSC1 gene","score":0.9355},{"id":"https://openalex.org/keywords/tuberin","display_name":"tuberin","score":0.6387},{"id":"https://openalex.org/keywords/hepatic-angiomyolipoma","display_name":"hepatic angiomyolipoma","score":0.8203},{"id":"https://openalex.org/keywords/cardiac-rhabdomyoma","display_name":"cardiac rhabdomyoma","score":0.4429},{"id":"https://openalex.org/keywords/subependymal-nodules","display_name":"subependymal nodules","score":0.8697},{"id":"https://openalex.org/keywords/hamartin","display_name":"hamartin","score":0.7821},{"id":"https://openalex.org/keywords/facial-angiofibroma","display_name":"facial angiofibroma","score":0.809},{"id":"https://openalex.org/keywords/tsc2-mutation","display_name":"TSC2 mutation","score":0.6982},{"id":"https://openalex.org/keywords/fibrofolliculoma","display_name":"fibrofolliculoma","score":0.6851},{"id":"https://openalex.org/keywords/cystic-lung-disease","display_name":"cystic lung disease","score":0.2433},{"id":"https://openalex.org/keywords/angiofibroma","display_name":"angiofibroma","score":0.32},{"id":"https://openalex.org/keywords/epithelioid-angiomyolipoma","display_name":"epithelioid angiomyolipoma","score":0.7403}],"legacy_keywords":"Tuberous Sclerosis Complex; Lymphangioleiomyomatosis; Angiomyolipoma; mTOR Inhibitors; Neurological Manifestations; Genetic Mutations; Epilepsy; Diagnostic Criteria; Hamartin and Tuberin Proteins; Cognitive Impairment","ids":{"openalex":"https://openalex.org/T12049","wikipedia":"https://en.wikipedia.org/wiki/Tuberous_sclerosis"},"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases"},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation"},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments"},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects"},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments"},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research"},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health"},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging"},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders"},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence"},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research"},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses"},{"id":"https://openalex.org/T11238","display_name":"Simulation-Based Education in Healthcare"},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control"},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism"},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions"},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research"},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments"},{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment"},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology"},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies"},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques"},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology"},{"id":"https://openalex.org/T12625","display_name":"Sympathectomy and Hyperhidrosis Treatments"},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health"},{"id":"https://openalex.org/T13044","display_name":"Biofield Effects and Biophysics"},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation"},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals"},{"id":"https://openalex.org/T14344","display_name":"Pathogenesis and Treatment of Hiccups"}],"works_count":22614,"cited_by_count":296864,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12049","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:12"}