{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","description":"This cluster of papers focuses on the use of Poly(ADP-ribose) Polymerase (PARP) inhibitors, such as Olaparib and Niraparib, as a targeted therapy for cancer, particularly in the context of BRCA mutations and DNA repair deficiency. The concept of synthetic lethality, homologous recombination, and the therapeutic potential of PARP inhibitors in various cancers, including platinum-sensitive ovarian cancer, are extensively explored.","keywords":[{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.5175},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.5984},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.4002},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.2246},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.711},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.3221},{"id":"https://openalex.org/keywords/niraparib","display_name":"niraparib","score":0.725},{"id":"https://openalex.org/keywords/parp-inhibition","display_name":"PARP inhibition","score":0.4343},{"id":"https://openalex.org/keywords/rucaparib","display_name":"rucaparib","score":0.7277},{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.6375},{"id":"https://openalex.org/keywords/veliparib","display_name":"veliparib","score":0.6724},{"id":"https://openalex.org/keywords/parp1-inhibitors","display_name":"PARP-1 inhibitors","score":0.4969},{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.2779},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.2109},{"id":"https://openalex.org/keywords/parp2","display_name":"PARP2","score":0.4666},{"id":"https://openalex.org/keywords/poly-adp-ribose-glycohydrolase","display_name":"poly(ADP-ribose) glycohydrolase","score":0.467},{"id":"https://openalex.org/keywords/atr-inhibitors","display_name":"ATR inhibitors","score":0.2495},{"id":"https://openalex.org/keywords/poly-adp-ribose","display_name":"poly(ADP-ribose)","score":0.2347},{"id":"https://openalex.org/keywords/platinum-sensitive-recurrent-ovarian-cancer","display_name":"platinum-sensitive recurrent ovarian cancer","score":0.6386},{"id":"https://openalex.org/keywords/germline-brca-mutation","display_name":"germline BRCA mutation","score":0.5599},{"id":"https://openalex.org/keywords/parp-inhibitor-sensitivity","display_name":"PARP inhibitor sensitivity","score":0.4663},{"id":"https://openalex.org/keywords/parp1-inhibition","display_name":"PARP1 inhibition","score":0.3541},{"id":"https://openalex.org/keywords/brcaness","display_name":"BRCAness","score":0.3827},{"id":"https://openalex.org/keywords/platinum-sensitive-ovarian-cancer","display_name":"platinum-sensitive ovarian cancer","score":0.2972},{"id":"https://openalex.org/keywords/rad51-foci","display_name":"RAD51 foci","score":0.2419}],"legacy_keywords":"PARP Inhibitors; BRCA Mutation; DNA Repair; Olaparib; Synthetic Lethality; Homologous Recombination; Cancer Therapy; Platinum-Sensitive Ovarian Cancer; BRCA1/2 Deficiency; Cell Death","ids":{"openalex":"https://openalex.org/T11914","wikipedia":"https://en.wikipedia.org/wiki/PARP_inhibitor"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms"},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research"},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":22030,"cited_by_count":405326,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11914","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:12"}