{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","description":"This cluster of papers focuses on the classification, diagnosis, and treatment of histiocytic disorders, including Langerhans Cell Histiocytosis and Erdheim-Chester Disease. It explores the role of BRAF mutations, immunohistochemical approaches to classification, and consensus guidelines for clinical management. The papers also delve into the pathogenesis, molecular characterization, and therapy intensification for multisystem involvement.","keywords":[{"id":"https://openalex.org/keywords/langerhans-cell-histiocytosis","display_name":"Langerhans cell histiocytosis","score":0.8152},{"id":"https://openalex.org/keywords/rosai-dorfman-disease","display_name":"Rosai-Dorfman disease","score":0.9269},{"id":"https://openalex.org/keywords/erdheim-chester-disease","display_name":"Erdheim-Chester disease","score":0.8807},{"id":"https://openalex.org/keywords/histiocytosis","display_name":"histiocytosis","score":0.6459},{"id":"https://openalex.org/keywords/eosinophilic-granuloma","display_name":"eosinophilic granuloma","score":0.5494},{"id":"https://openalex.org/keywords/non-langerhans-cell-histiocytosis","display_name":"non-Langerhans cell histiocytosis","score":0.9584},{"id":"https://openalex.org/keywords/juvenile-xanthogranuloma","display_name":"juvenile xanthogranuloma","score":0.8266},{"id":"https://openalex.org/keywords/cd1a","display_name":"CD1a","score":0.3321},{"id":"https://openalex.org/keywords/histiocytic-disorders","display_name":"histiocytic disorders","score":0.8702},{"id":"https://openalex.org/keywords/pulmonary-langerhans-cell-histiocytosis","display_name":"pulmonary Langerhans cell histiocytosis","score":0.7124},{"id":"https://openalex.org/keywords/adult-langerhans-cell-histiocytosis","display_name":"adult-onset Langerhans cell histiocytosis","score":0.9828},{"id":"https://openalex.org/keywords/hand-schuller-christian-disease","display_name":"Hand-Sch\u00fcller-Christian disease","score":0.8994},{"id":"https://openalex.org/keywords/blastic-plasmacytoid-dendritic-cell-neoplasm","display_name":"blastic plasmacytoid dendritic cell neoplasm","score":0.4851},{"id":"https://openalex.org/keywords/emperipolesis","display_name":"emperipolesis","score":0.6121},{"id":"https://openalex.org/keywords/letterer-siwe-disease","display_name":"Letterer-Siwe disease","score":0.8952},{"id":"https://openalex.org/keywords/histiocytic-sarcoma","display_name":"histiocytic sarcoma","score":0.4855},{"id":"https://openalex.org/keywords/malignant-histiocytosis","display_name":"malignant histiocytosis","score":0.5755},{"id":"https://openalex.org/keywords/histiocytic-neoplasms","display_name":"histiocytic neoplasms","score":0.7912},{"id":"https://openalex.org/keywords/multicentric-reticulohistiocytosis","display_name":"multicentric reticulohistiocytosis","score":0.8181},{"id":"https://openalex.org/keywords/follicular-dendritic-cell-sarcoma","display_name":"follicular dendritic cell sarcoma","score":0.542},{"id":"https://openalex.org/keywords/cutaneous-langerhans-cell-histiocytosis","display_name":"cutaneous Langerhans cell histiocytosis","score":0.966},{"id":"https://openalex.org/keywords/cutaneous-histiocytosis","display_name":"cutaneous histiocytosis","score":0.8558},{"id":"https://openalex.org/keywords/histiocytic-proliferation","display_name":"histiocytic proliferation","score":0.7111},{"id":"https://openalex.org/keywords/xanthogranuloma","display_name":"xanthogranuloma","score":0.4467},{"id":"https://openalex.org/keywords/birbeck-granules","display_name":"Birbeck granules","score":0.4358}],"legacy_keywords":"Langerhans Cell Histiocytosis; Erdheim-Chester Disease; Dendritic Cell Neoplasms; BRAF Mutations; Clinical Management; Immunohistochemical Approach; Multisystem Involvement; Therapy Intensification; Pathogenesis; Molecular Characterization","ids":{"openalex":"https://openalex.org/T11909","wikipedia":"https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis"},"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases"},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation"},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments"},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects"},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments"},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research"},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health"},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging"},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders"},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence"},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research"},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses"},{"id":"https://openalex.org/T11238","display_name":"Simulation-Based Education in Healthcare"},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control"},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism"},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions"},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research"},{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment"},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology"},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research"},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies"},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques"},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology"},{"id":"https://openalex.org/T12625","display_name":"Sympathectomy and Hyperhidrosis Treatments"},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health"},{"id":"https://openalex.org/T13044","display_name":"Biofield Effects and Biophysics"},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation"},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals"},{"id":"https://openalex.org/T14344","display_name":"Pathogenesis and Treatment of Hiccups"}],"works_count":33568,"cited_by_count":294269,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11909","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:12"}