{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","description":"This cluster of papers focuses on the structure, function, and dysfunction of the blood-brain barrier, as well as the interactions between astrocytes, endothelial cells, and pericytes in the neurovascular unit. It covers topics such as tight junctions, CNS drug delivery, neurological diseases, and the role of various cell types in maintaining vascular homeostasis.","keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.2552},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.2547},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.3318},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.2451},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.2724},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.4383},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.2148},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.2341},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.422},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.2059},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.5232},{"id":"https://openalex.org/keywords/cerebral-microvasculature","display_name":"cerebral microvasculature","score":0.3157},{"id":"https://openalex.org/keywords/neurovascular-unit","display_name":"neurovascular unit","score":0.3433},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.3613},{"id":"https://openalex.org/keywords/blood-cerebrospinal-fluid-barrier","display_name":"blood-CSF barrier","score":0.3202},{"id":"https://openalex.org/keywords/blood-brain-barrier-integrity","display_name":"blood-brain barrier integrity","score":0.3637},{"id":"https://openalex.org/keywords/transendothelial-electrical-resistance","display_name":"transendothelial electrical resistance","score":0.5493},{"id":"https://openalex.org/keywords/blood-brain-barrier-dysfunction","display_name":"blood-brain barrier dysfunction","score":0.3719},{"id":"https://openalex.org/keywords/claudins","display_name":"claudins","score":0.324},{"id":"https://openalex.org/keywords/in-vitro-bbb-model","display_name":"in vitro BBB model","score":0.8621},{"id":"https://openalex.org/keywords/brain-capillaries","display_name":"brain capillaries","score":0.5317},{"id":"https://openalex.org/keywords/endothelial-junctions","display_name":"endothelial junctions","score":0.2244},{"id":"https://openalex.org/keywords/claudin-2","display_name":"claudin-2","score":0.2209},{"id":"https://openalex.org/keywords/brain-endothelium","display_name":"brain endothelium","score":0.4372},{"id":"https://openalex.org/keywords/barrier-permeability","display_name":"barrier permeability","score":0.515}],"legacy_keywords":"Blood-Brain Barrier; Neurovascular Unit; Tight Junctions; Pericytes; Endothelial Cells; Astrocyte Interactions; Barrier Dysfunction; CNS Drug Delivery; Neurological Diseases; Vascular Homeostasis","ids":{"openalex":"https://openalex.org/T11872","wikipedia":"https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier"},"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders"},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies"},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms"},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research"},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification"},{"id":"https://openalex.org/T12854","display_name":"Neurology and Historical Studies"},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism"},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments"},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments"}],"works_count":49587,"cited_by_count":1695697,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11872","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:12"}