{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","description":"This cluster of papers focuses on the innate immune response to viral infection, particularly the role of pattern recognition receptors such as RIG-I-like receptors and the cGAS-STING pathway in detecting viral nucleic acids and activating antiviral signaling. It also explores the mechanisms of interferon signaling, immune sensing of DNA and RNA viruses, and the regulation of antiviral responses.","keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.3693},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.2943},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.2353},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.4101},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.5897},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.2123},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.3114},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.4313},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.5626},{"id":"https://openalex.org/keywords/interferon-induction","display_name":"interferon induction","score":0.6614},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.4895},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.3123},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.3084},{"id":"https://openalex.org/keywords/interferon-production","display_name":"interferon production","score":0.6007},{"id":"https://openalex.org/keywords/mda5","display_name":"MDA5","score":0.4658},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.3346},{"id":"https://openalex.org/keywords/antiviral-defense","display_name":"antiviral defense","score":0.2534},{"id":"https://openalex.org/keywords/antiviral-response","display_name":"antiviral response","score":0.3132},{"id":"https://openalex.org/keywords/cgas","display_name":"cGAS","score":0.5069},{"id":"https://openalex.org/keywords/mavs","display_name":"MAVS","score":0.6151},{"id":"https://openalex.org/keywords/cytosolic-dna-sensing","display_name":"cytosolic DNA sensing","score":0.6118},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.3761},{"id":"https://openalex.org/keywords/irf7","display_name":"IRF7","score":0.3745},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.2245},{"id":"https://openalex.org/keywords/antiviral-signaling","display_name":"antiviral signaling","score":0.6264}],"legacy_keywords":"Innate Immunity; Viral Infection; Interferon Signaling; Pattern Recognition Receptors; cGAS-STING Pathway; RIG-I-like Receptors; Antiviral Response; Type I Interferons; Immune Sensing; Inflammatory Disease","ids":{"openalex":"https://openalex.org/T11668","wikipedia":"https://en.wikipedia.org/wiki/Innate_immune_system"},"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology"},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation"},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis"},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota"},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses"},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases"},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction"},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer"},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine"},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms"},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy"},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms"},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders"},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies"},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods"},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology"},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins"},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways"},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation"},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases"},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor"},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations"},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses"},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways"},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms"}],"works_count":57741,"cited_by_count":1657885,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11668","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:11"}