{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","description":"This cluster of papers explores the role of NF-?B signaling in inflammation, immunity, and cancer. It covers various aspects such as the regulation of NF-?B activity, the link between NF-?B and inflammatory diseases, the impact of NF-?B on cancer development and progression, and the crosstalk with other signaling pathways. The papers also discuss potential therapeutic strategies targeting the NF-?B pathway.","keywords":[{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.2326},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.3208},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.4114},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.3179},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.3002},{"id":"https://openalex.org/keywords/traf2","display_name":"TRAF2","score":0.3316},{"id":"https://openalex.org/keywords/nf-kappab-inhibitors","display_name":"NF-\u03baB inhibitors","score":0.3205},{"id":"https://openalex.org/keywords/c-rel","display_name":"c-Rel","score":0.4237},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.2223},{"id":"https://openalex.org/keywords/ikkalpha","display_name":"IKK\u03b1","score":0.3975},{"id":"https://openalex.org/keywords/nik","display_name":"NIK","score":0.4613},{"id":"https://openalex.org/keywords/relb","display_name":"RelB","score":0.3598},{"id":"https://openalex.org/keywords/non-canonical-nf-kappab-signaling","display_name":"non-canonical NF-\u03baB signaling","score":0.4531},{"id":"https://openalex.org/keywords/ikappab","display_name":"I\u03baB","score":0.2993},{"id":"https://openalex.org/keywords/rela-p65","display_name":"RelA/p65","score":0.4291},{"id":"https://openalex.org/keywords/ikappab-degradation","display_name":"I\u03baB degradation","score":0.3698},{"id":"https://openalex.org/keywords/malt1","display_name":"MALT1","score":0.3334},{"id":"https://openalex.org/keywords/ikappab-phosphorylation","display_name":"I\u03baB phosphorylation","score":0.271},{"id":"https://openalex.org/keywords/bcl10","display_name":"BCL10","score":0.3202},{"id":"https://openalex.org/keywords/traf3","display_name":"TRAF3","score":0.2162},{"id":"https://openalex.org/keywords/ikappabbeta","display_name":"I\u03baB\u03b2","score":0.6162},{"id":"https://openalex.org/keywords/p52","display_name":"p52","score":0.4855},{"id":"https://openalex.org/keywords/p50-subunit","display_name":"p50 subunit","score":0.4882},{"id":"https://openalex.org/keywords/ikk-complex","display_name":"IKK complex","score":0.7305},{"id":"https://openalex.org/keywords/ikappab-kinase-beta","display_name":"I\u03baB kinase \u03b2","score":0.3976}],"legacy_keywords":"NF-?B; signaling; inflammation; cancer; immunity; ubiquitination; transcription factors; TNF-a; IKK; regulation","ids":{"openalex":"https://openalex.org/T11591","wikipedia":"https://en.wikipedia.org/wiki/NF-%CE%BAB"},"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation"},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies"},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment"},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research"},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms"},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism"},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics"},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies"},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism"},{"id":"https://openalex.org/T13350","display_name":"Myxozoan Parasites in Aquatic Species"},{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies"},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity"}],"works_count":30236,"cited_by_count":1490035,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11591","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:11"}