{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","description":"This cluster of papers focuses on the cardiotoxic effects of various cancer treatments, particularly anthracyclines and related drugs like doxorubicin and trastuzumab. It explores the molecular mechanisms, pharmacologic developments, early detection, prevention, and management of cardiotoxicity in cancer patients. The papers also discuss the long-term cardiovascular complications and survival outcomes in individuals undergoing these treatments.","keywords":[{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.2952},{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.7963},{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiotoxicity","display_name":"chemotherapy-induced cardiotoxicity","score":0.8373},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.7124},{"id":"https://openalex.org/keywords/cardio-oncology","display_name":"cardio-oncology","score":0.6057},{"id":"https://openalex.org/keywords/anthracycline-based-chemotherapy","display_name":"anthracycline chemotherapy","score":0.21},{"id":"https://openalex.org/keywords/radiation-induced-cardiotoxicity","display_name":"radiation-induced cardiotoxicity","score":0.3822},{"id":"https://openalex.org/keywords/dexrazoxane","display_name":"dexrazoxane","score":0.6148},{"id":"https://openalex.org/keywords/anthracycline-induced-cardiomyopathy","display_name":"anthracycline-induced cardiomyopathy","score":0.7884},{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiomyopathy","display_name":"chemotherapy-induced cardiomyopathy","score":0.7934},{"id":"https://openalex.org/keywords/cancer-therapy-related-cardiotoxicity","display_name":"cancer therapy-related cardiotoxicity","score":0.7223},{"id":"https://openalex.org/keywords/cardiotoxicity-prevention","display_name":"cardiotoxicity prevention","score":0.8767},{"id":"https://openalex.org/keywords/early-detection-of-cardiotoxicity","display_name":"early detection of cardiotoxicity","score":0.9408},{"id":"https://openalex.org/keywords/cumulative-anthracycline-dose","display_name":"cumulative anthracycline dose","score":0.8986},{"id":"https://openalex.org/keywords/cancer-therapy-related-cardiac-dysfunction","display_name":"cancer therapy-related cardiac dysfunction","score":0.8807},{"id":"https://openalex.org/keywords/radiation-induced-heart-disease","display_name":"radiation-induced heart disease","score":0.2381},{"id":"https://openalex.org/keywords/drug-induced-cardiomyopathy","display_name":"drug-induced cardiomyopathy","score":0.2888},{"id":"https://openalex.org/keywords/adriamycin-cardiotoxicity","display_name":"adriamycin cardiotoxicity","score":0.6263},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiomyopathy","display_name":"doxorubicin-induced cardiomyopathy","score":0.5874},{"id":"https://openalex.org/keywords/cardiac-function-monitoring","display_name":"cardiac function monitoring","score":0.2657},{"id":"https://openalex.org/keywords/subclinical-cardiotoxicity","display_name":"subclinical cardiotoxicity","score":0.9101},{"id":"https://openalex.org/keywords/trastuzumab-cardiotoxicity","display_name":"trastuzumab cardiotoxicity","score":0.7184},{"id":"https://openalex.org/keywords/cardiotoxicity-prediction","display_name":"cardiotoxicity prediction","score":0.4361},{"id":"https://openalex.org/keywords/cardiotoxicity-monitoring","display_name":"cardiotoxicity monitoring","score":0.8173},{"id":"https://openalex.org/keywords/late-cardiotoxicity","display_name":"late cardiotoxicity","score":0.8757}],"legacy_keywords":"Anthracyclines; Doxorubicin; Cardiomyopathy; Chemotherapy; Cardiovascular Complications; Trastuzumab; Oxidative Stress; Cardiac Dysfunction; Prevention; Survivors","ids":{"openalex":"https://openalex.org/T11535","wikipedia":"https://en.wikipedia.org/wiki/Cardiotoxicity"},"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes"},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies"},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments"},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management"},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias"},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research"},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies"},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control"},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors"},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies"},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention"},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies"},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis"},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases"},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health"},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research"},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments"},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi"},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise"},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes"},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling"},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena"},{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy"},{"id":"https://openalex.org/T12291","display_name":"Pericarditis and Cardiac Tamponade"},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity"},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health"},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders"},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors"}],"works_count":35102,"cited_by_count":629466,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11535","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:10"}