{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","description":"This cluster of papers focuses on the role of STAT3 in cancer inflammation and immunity, with a particular emphasis on its involvement in cytokine signaling, regulation of the JAK/STAT pathway, modulation of the immune response, and its impact on the tumor microenvironment. The cluster also explores the interplay between STAT3, IL-6, and SOCS proteins in transcriptional control, inflammation, and cancer progression.","keywords":[{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.2811},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.4549},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.2232},{"id":"https://openalex.org/keywords/cytokine-receptors","display_name":"cytokine receptors","score":0.3365},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.2287},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.2102},{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signaling","display_name":"suppressor of cytokine signaling","score":0.4504},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.3178},{"id":"https://openalex.org/keywords/socs1","display_name":"SOCS1","score":0.2197},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.3149},{"id":"https://openalex.org/keywords/il-6-signaling","display_name":"IL-6 signaling","score":0.2413},{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":0.2195},{"id":"https://openalex.org/keywords/janus-kinase","display_name":"Janus kinase","score":0.5388},{"id":"https://openalex.org/keywords/stat3-inhibitor","display_name":"STAT3 inhibitor","score":0.4006},{"id":"https://openalex.org/keywords/cytokine-receptor-signaling","display_name":"cytokine receptor signaling","score":0.4778},{"id":"https://openalex.org/keywords/soluble-il-6-receptor","display_name":"soluble IL-6 receptor","score":0.2338},{"id":"https://openalex.org/keywords/jak3","display_name":"JAK3","score":0.2886},{"id":"https://openalex.org/keywords/signal-transducer-and-activator-of-transcription","display_name":"signal transducer and activator of transcription","score":0.6382},{"id":"https://openalex.org/keywords/tyk2","display_name":"TYK2","score":0.2552},{"id":"https://openalex.org/keywords/stat5a","display_name":"STAT5A","score":0.2869},{"id":"https://openalex.org/keywords/stat-proteins","display_name":"STAT proteins","score":0.6154},{"id":"https://openalex.org/keywords/ag490","display_name":"AG490","score":0.2433},{"id":"https://openalex.org/keywords/stat5b","display_name":"STAT5B","score":0.2511},{"id":"https://openalex.org/keywords/gm-csf-receptor","display_name":"GM-CSF receptor","score":0.3784},{"id":"https://openalex.org/keywords/stat3-inhibition","display_name":"STAT3 inhibition","score":0.2343}],"legacy_keywords":"STAT3; IL-6; JAK/STAT pathway; inflammation; cancer; cytokine signaling; immune response; SOCS proteins; tumor microenvironment; transcriptional control","ids":{"openalex":"https://openalex.org/T11503","wikipedia":"https://en.wikipedia.org/wiki/STAT3"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms"},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":45313,"cited_by_count":1760969,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11503","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:10"}