{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","description":"This cluster of papers focuses on Chimeric Antigen Receptor (CAR) T cell therapy, a form of immunotherapy that uses genetically engineered T cells to target and destroy cancer cells. The papers cover various aspects of CAR T cell therapy, including its application in treating leukemia, lymphoma, and solid tumors, the management of cytokine release syndrome associated with this therapy, and the long-term efficacy and safety of CAR T cell treatment.","keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.6092},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.6683},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.7659},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.5186},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.2038},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.36},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.2379},{"id":"https://openalex.org/keywords/axicabtagene-ciloleucel","display_name":"axicabtagene ciloleucel","score":0.8728},{"id":"https://openalex.org/keywords/immune-effector-cell-associated-neurotoxicity-syndrome","display_name":"immune effector cell-associated neurotoxicity syndrome","score":0.7043},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.2086},{"id":"https://openalex.org/keywords/tisagenlecleucel","display_name":"tisagenlecleucel","score":0.8318},{"id":"https://openalex.org/keywords/car-t-cell-persistence","display_name":"CAR T cell persistence","score":0.9412},{"id":"https://openalex.org/keywords/b-cell-maturation-antigen","display_name":"BCMA","score":0.3548},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.2056},{"id":"https://openalex.org/keywords/t-cell-engineering","display_name":"T cell engineering","score":0.6316},{"id":"https://openalex.org/keywords/cd19-car-t-cell-therapy","display_name":"CD19 CAR T-cell therapy","score":0.7925},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.6279},{"id":"https://openalex.org/keywords/large-b-cell-lymphoma","display_name":"large B-cell lymphoma","score":0.3539},{"id":"https://openalex.org/keywords/cd19-car-t-cells","display_name":"CD19 CAR T cells","score":0.8522},{"id":"https://openalex.org/keywords/car-nk-cells","display_name":"CAR-NK cells","score":0.5318},{"id":"https://openalex.org/keywords/on-target-off-tumor-toxicity","display_name":"on-target off-tumor toxicity","score":0.6242},{"id":"https://openalex.org/keywords/car-t-cell-manufacturing","display_name":"CAR T cell manufacturing","score":0.8959},{"id":"https://openalex.org/keywords/car-t-cell-expansion","display_name":"CAR-T cell expansion","score":0.9282},{"id":"https://openalex.org/keywords/mesothelin","display_name":"mesothelin","score":0.2219},{"id":"https://openalex.org/keywords/allogeneic-car-t-cells","display_name":"allogeneic CAR T cells","score":0.9439}],"legacy_keywords":"CAR T Cells; Chimeric Antigen Receptor; T Cell Therapy; Leukemia; Lymphoma; Immunotherapy; Cytokine Release Syndrome; Tumor Regression; Adoptive Cell Transfer; Cancer Immunotherapy","ids":{"openalex":"https://openalex.org/T11491","wikipedia":"https://en.wikipedia.org/wiki/Chimeric_antigen_receptor_T_cell"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms"},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":49928,"cited_by_count":866731,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11491","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:10"}