{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","description":"This cluster of papers explores the intricate relationship between the immune system and the brain, focusing on neuroinflammation, cytokine signaling, and the impact of immune activation on psychiatric disorders such as depression and schizophrenia. The role of tryptophan metabolism, oxidative stress, and maternal immune activation in influencing brain function and behavior is also a key area of investigation.","keywords":[{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.2671},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.4766},{"id":"https://openalex.org/keywords/kynurenic-acid","display_name":"kynurenic acid","score":0.4219},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.3448},{"id":"https://openalex.org/keywords/quinolinic-acid","display_name":"quinolinic acid","score":0.349},{"id":"https://openalex.org/keywords/3-hydroxykynurenine","display_name":"3-hydroxykynurenine","score":0.5845},{"id":"https://openalex.org/keywords/tryptophan-2-3-dioxygenase","display_name":"tryptophan 2,3-dioxygenase","score":0.3284},{"id":"https://openalex.org/keywords/maternal-immune-activation","display_name":"maternal immune activation","score":0.2848},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.2391},{"id":"https://openalex.org/keywords/tryptophan-metabolites","display_name":"tryptophan metabolites","score":0.231},{"id":"https://openalex.org/keywords/tryptophan-catabolism","display_name":"tryptophan catabolism","score":0.2485},{"id":"https://openalex.org/keywords/xanthurenic-acid","display_name":"xanthurenic acid","score":0.3856},{"id":"https://openalex.org/keywords/kynurenine-tryptophan-ratio","display_name":"kynurenine/tryptophan ratio","score":0.4086},{"id":"https://openalex.org/keywords/3-hydroxyanthranilic-acid","display_name":"3-hydroxyanthranilic acid","score":0.3892},{"id":"https://openalex.org/keywords/tryptophan-depletion","display_name":"tryptophan depletion","score":0.2779},{"id":"https://openalex.org/keywords/plasma-tryptophan","display_name":"plasma tryptophan","score":0.4705},{"id":"https://openalex.org/keywords/kynurenine-3-monooxygenase","display_name":"kynurenine 3-monooxygenase","score":0.528},{"id":"https://openalex.org/keywords/l-kynurenine","display_name":"L-kynurenine","score":0.3854},{"id":"https://openalex.org/keywords/kynureninase","display_name":"kynureninase","score":0.3811},{"id":"https://openalex.org/keywords/kynurenine-aminotransferase","display_name":"kynurenine aminotransferase","score":0.6121},{"id":"https://openalex.org/keywords/kynurenine-metabolism","display_name":"kynurenine metabolism","score":0.4895},{"id":"https://openalex.org/keywords/kynurenine-metabolites","display_name":"kynurenine metabolites","score":0.5921},{"id":"https://openalex.org/keywords/kynurenine-aminotransferase-ii","display_name":"kynurenine aminotransferase II","score":0.7194},{"id":"https://openalex.org/keywords/prenatal-immune-activation","display_name":"prenatal immune activation","score":0.4243},{"id":"https://openalex.org/keywords/acute-tryptophan-depletion","display_name":"acute tryptophan depletion","score":0.4179}],"legacy_keywords":"Neuroinflammation; Cytokines; Depression; Tryptophan Metabolism; Immune Activation; Schizophrenia; Oxidative Stress; Microglia; Maternal Immune Activation; Antidepressant Treatment","ids":{"openalex":"https://openalex.org/T11337","wikipedia":"https://en.wikipedia.org/wiki/Neuroimmunology"},"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[],"works_count":28135,"cited_by_count":851410,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11337","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:10"}