{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","description":"This cluster of papers focuses on the pathogenesis, clinical manifestations, and treatment of systemic sclerosis, with an emphasis on fibrosis, autoantibodies, pulmonary involvement, and the role of TGF-\u00df signaling. It also explores genetic markers, endothelial dysfunction, and various treatment approaches including immunosuppressive therapy for this complex autoimmune disease.","keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.6298},{"id":"https://openalex.org/keywords/raynaud-s-phenomenon","display_name":"Raynaud's phenomenon","score":0.5264},{"id":"https://openalex.org/keywords/diffuse-cutaneous-systemic-sclerosis","display_name":"diffuse cutaneous systemic sclerosis","score":0.9194},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.4845},{"id":"https://openalex.org/keywords/limited-cutaneous-systemic-sclerosis","display_name":"limited cutaneous systemic sclerosis","score":0.8797},{"id":"https://openalex.org/keywords/localized-scleroderma","display_name":"morphea","score":0.6599},{"id":"https://openalex.org/keywords/digital-ulcers","display_name":"digital ulcers","score":0.8585},{"id":"https://openalex.org/keywords/mixed-connective-tissue-disease","display_name":"mixed connective tissue disease","score":0.3645},{"id":"https://openalex.org/keywords/anticentromere-antibodies","display_name":"anti-centromere antibodies","score":0.7009},{"id":"https://openalex.org/keywords/anti-scl-70-antibodies","display_name":"anti-Scl-70 antibodies","score":0.7817},{"id":"https://openalex.org/keywords/nailfold-capillaroscopy","display_name":"nailfold capillaroscopy","score":0.5104},{"id":"https://openalex.org/keywords/modified-rodnan-skin-score","display_name":"modified Rodnan skin score","score":0.9472},{"id":"https://openalex.org/keywords/scleroderma-renal-crisis","display_name":"scleroderma renal crisis","score":0.8098},{"id":"https://openalex.org/keywords/vasculopathy","display_name":"vasculopathy","score":0.2886},{"id":"https://openalex.org/keywords/capillaroscopy","display_name":"capillaroscopy","score":0.3678},{"id":"https://openalex.org/keywords/primary-raynaud-s-phenomenon","display_name":"primary Raynaud's phenomenon","score":0.8573},{"id":"https://openalex.org/keywords/digital-ischemia","display_name":"digital ischemia","score":0.3514},{"id":"https://openalex.org/keywords/nailfold-videocapillaroscopy","display_name":"nailfold videocapillaroscopy","score":0.6989},{"id":"https://openalex.org/keywords/parry-romberg-syndrome","display_name":"Parry-Romberg syndrome","score":0.6743},{"id":"https://openalex.org/keywords/crest-syndrome","display_name":"CREST syndrome","score":0.5311},{"id":"https://openalex.org/keywords/secondary-raynaud-phenomenon","display_name":"secondary Raynaud's phenomenon","score":0.8513},{"id":"https://openalex.org/keywords/sclerodactyly","display_name":"sclerodactyly","score":0.7044},{"id":"https://openalex.org/keywords/linear-scleroderma","display_name":"linear scleroderma","score":0.7218},{"id":"https://openalex.org/keywords/skin-thickening","display_name":"skin thickening","score":0.2738},{"id":"https://openalex.org/keywords/systemic-sclerosis-associated-interstitial-lung-disease","display_name":"systemic sclerosis-associated interstitial lung disease","score":0.705}],"legacy_keywords":"Systemic Sclerosis; Fibrosis; Autoantibodies; Pulmonary Involvement; Treatment; Raynaud's Phenomenon; Genetic Markers; Endothelial Dysfunction; TGF-\u00df Signaling; Immunosuppressive Therapy","ids":{"openalex":"https://openalex.org/T11330","wikipedia":"https://en.wikipedia.org/wiki/Systemic_sclerosis"},"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies"},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment"},{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology"},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies"},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research"},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion"},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas"},{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals"},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects"},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research"},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer"},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects"},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders"},{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases"},{"id":"https://openalex.org/T12193","display_name":"Trigeminal Neuralgia and Treatments"},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation"},{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment"},{"id":"https://openalex.org/T13383","display_name":"Tumors and Oncological Cases"},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy"},{"id":"https://openalex.org/T13834","display_name":"Whipple's Disease and Interleukins"},{"id":"https://openalex.org/T14199","display_name":"Historical and Scientific Studies"},{"id":"https://openalex.org/T14415","display_name":"Biomedical Research and Pathophysiology"}],"works_count":58635,"cited_by_count":767957,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11330","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:10"}