{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","description":"This cluster of papers focuses on the use of bisphosphonates in the treatment of bone metastases and associated complications, particularly osteonecrosis of the jaw. It explores the mechanisms of action, clinical features, and therapeutic opportunities for bisphosphonates in cancer treatment, with a specific emphasis on prostate and breast cancer. The papers also discuss the role of bisphosphonates in maintaining bone health and preventing skeletal complications in cancer patients.","keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.3552},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.4997},{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.7256},{"id":"https://openalex.org/keywords/bisphosphonate-related-osteonecrosis-of-the-jaw","display_name":"bisphosphonate-related osteonecrosis of the jaw","score":0.912},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.3082},{"id":"https://openalex.org/keywords/medication-related-osteonecrosis-of-the-jaw","display_name":"medication-related osteonecrosis of the jaw","score":0.8846},{"id":"https://openalex.org/keywords/skeletal-related-events","display_name":"skeletal-related events","score":0.6428},{"id":"https://openalex.org/keywords/pamidronate","display_name":"pamidronate","score":0.4405},{"id":"https://openalex.org/keywords/antiresorptive-agents","display_name":"antiresorptive agents","score":0.3399},{"id":"https://openalex.org/keywords/ibandronate","display_name":"ibandronate","score":0.3904},{"id":"https://openalex.org/keywords/antiresorptive-therapy","display_name":"antiresorptive therapy","score":0.2275},{"id":"https://openalex.org/keywords/clodronate","display_name":"clodronate","score":0.4375},{"id":"https://openalex.org/keywords/hypercalcemia-of-malignancy","display_name":"hypercalcemia of malignancy","score":0.3133},{"id":"https://openalex.org/keywords/intravenous-bisphosphonates","display_name":"intravenous bisphosphonates","score":0.5627},{"id":"https://openalex.org/keywords/oral-bisphosphonates","display_name":"oral bisphosphonates","score":0.4935},{"id":"https://openalex.org/keywords/breast-cancer-bone-metastasis","display_name":"breast cancer bone metastasis","score":0.2714},{"id":"https://openalex.org/keywords/bisphosphonate-adverse-effects","display_name":"bisphosphonate adverse effects","score":0.6219},{"id":"https://openalex.org/keywords/drug-induced-bone-disease","display_name":"drug-induced bone disease","score":0.4584},{"id":"https://openalex.org/keywords/osteoclast-inhibition","display_name":"osteoclast inhibition","score":0.3303},{"id":"https://openalex.org/keywords/bone-resorption-inhibition","display_name":"bone resorption inhibition","score":0.3007},{"id":"https://openalex.org/keywords/bisphosphonate-therapy","display_name":"bisphosphonate therapy","score":0.2225},{"id":"https://openalex.org/keywords/nitrogen-containing-bisphosphonates","display_name":"nitrogen-containing bisphosphonates","score":0.5889},{"id":"https://openalex.org/keywords/rankl-inhibition","display_name":"RANKL inhibition","score":0.2294},{"id":"https://openalex.org/keywords/bone-modifying-agents","display_name":"bone-modifying agents","score":0.6791},{"id":"https://openalex.org/keywords/osteolytic-bone-metastasis","display_name":"osteolytic bone metastasis","score":0.2543}],"legacy_keywords":"Bisphosphonates; Osteonecrosis of the Jaw; Bone Metastasis; Cancer Treatment; Skeletal Complications; Mechanism of Action; Metastatic Bone Disease; Clinical Practice Guidelines; Prostate Cancer; Breast Cancer","ids":{"openalex":"https://openalex.org/T11221","wikipedia":"https://en.wikipedia.org/wiki/Bisphosphonate"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms"},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research"},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":34764,"cited_by_count":495817,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11221","updated_date":"2026-10-16T03:01:39","created_date":"2024-01-23T15:27:09"}