{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","description":"This cluster of papers explores the molecular mechanisms underlying osteoclast differentiation, bone resorption, and the regulation of bone homeostasis. It delves into the signaling pathways, transcription factors, and cytokines involved in osteoclast and osteoblast differentiation, as well as the interplay between the immune system and bone metabolism. 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remodeling","score":0.2549},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.5043},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.3279},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.2135},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.352},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.4894},{"id":"https://openalex.org/keywords/paget-s-disease-of-bone","display_name":"Paget's disease of bone","score":0.3881},{"id":"https://openalex.org/keywords/nfatc1","display_name":"NFATc1","score":0.5281},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.2278},{"id":"https://openalex.org/keywords/osteopetrosis","display_name":"osteopetrosis","score":0.5413},{"id":"https://openalex.org/keywords/osteoblast-proliferation","display_name":"osteoblast proliferation","score":0.2535},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.2113},{"id":"https://openalex.org/keywords/cathepsin-k","display_name":"cathepsin K","score":0.3746},{"id":"https://openalex.org/keywords/tartrate-resistant-acid-phosphatase","display_name":"tartrate-resistant acid phosphatase","score":0.3894},{"id":"https://openalex.org/keywords/rank","display_name":"RANK","score":0.2989},{"id":"https://openalex.org/keywords/osteoclast-precursors","display_name":"osteoclast precursors","score":0.7715},{"id":"https://openalex.org/keywords/osterix","display_name":"Osterix","score":0.3446},{"id":"https://openalex.org/keywords/bone-cells","display_name":"bone cells","score":0.2985},{"id":"https://openalex.org/keywords/osteoblastogenesis","display_name":"osteoblastogenesis","score":0.4561},{"id":"https://openalex.org/keywords/osteoclast-activity","display_name":"osteoclast activity","score":0.2372}],"legacy_keywords":"Osteoclast Differentiation; Bone Resorption; RANKL Signaling; Osteoblast Differentiation; Bone Formation; Regulation of Bone Homeostasis; Osteoprotegerin; Tumor Necrosis Factor-a; Oxidative Stress; Immune System Interactions","ids":{"openalex":"https://openalex.org/T11219","wikipedia":"https://en.wikipedia.org/wiki/Osteoclast"},"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies"},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics"},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health"},{"id":"https://openalex.org/T10123","display_name":"DNA Repair 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leukemia and cellular processes"},{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides"},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects"},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research"},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies"},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research"},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases"},{"id":"https://openalex.org/T11786","display_name":"Geomagnetism and Paleomagnetism Studies"},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study"},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function"},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and 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