{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","description":"This cluster of papers focuses on the genomic aberrations, treatment strategies, and prognostic factors associated with chronic lymphocytic leukemia (CLL). It covers topics such as the use of BTK inhibitors (e.g., Ibrutinib), the role of rituximab, TP53 mutations, and the impact of immunoglobulin mutations. Additionally, it explores therapeutic targets and outcomes in patients with Waldenstr\u00f6m macroglobulinemia.","keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.6519},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.5468},{"id":"https://openalex.org/keywords/ibrutinib","display_name":"ibrutinib","score":0.6019},{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.5935},{"id":"https://openalex.org/keywords/hairy-cell-leukemia","display_name":"hairy cell leukemia","score":0.6018},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.2193},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.2388},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.2385},{"id":"https://openalex.org/keywords/small-lymphocytic-lymphoma","display_name":"small lymphocytic lymphoma","score":0.5792},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.5384},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.2532},{"id":"https://openalex.org/keywords/zap-70","display_name":"ZAP-70","score":0.3987},{"id":"https://openalex.org/keywords/obinutuzumab","display_name":"obinutuzumab","score":0.4064},{"id":"https://openalex.org/keywords/lymphoplasmacytic-lymphoma","display_name":"lymphoplasmacytic lymphoma","score":0.4556},{"id":"https://openalex.org/keywords/acalabrutinib","display_name":"acalabrutinib","score":0.6622},{"id":"https://openalex.org/keywords/chlorambucil","display_name":"chlorambucil","score":0.2765},{"id":"https://openalex.org/keywords/ighv-mutation-status","display_name":"IGHV mutation status","score":0.9377},{"id":"https://openalex.org/keywords/cladribine","display_name":"cladribine","score":0.2688},{"id":"https://openalex.org/keywords/relapsed-refractory-disease","display_name":"relapsed/refractory disease","score":0.3058},{"id":"https://openalex.org/keywords/bendamustine","display_name":"bendamustine","score":0.245},{"id":"https://openalex.org/keywords/trisomy-12","display_name":"trisomy 12","score":0.7029},{"id":"https://openalex.org/keywords/relapsed-refractory-cll","display_name":"relapsed/refractory CLL","score":0.9724},{"id":"https://openalex.org/keywords/zanubrutinib","display_name":"zanubrutinib","score":0.5998},{"id":"https://openalex.org/keywords/idelalisib","display_name":"idelalisib","score":0.5231},{"id":"https://openalex.org/keywords/richter-transformation","display_name":"Richter transformation","score":0.8066}],"legacy_keywords":"Chronic Lymphocytic Leukemia; Genomic Aberrations; BTK Inhibitors; Rituximab; Ibrutinib; Prognostic Factors; TP53 Mutation; Waldenstr\u00f6m Macroglobulinemia; Immunoglobulin Mutation; Therapeutic Targets","ids":{"openalex":"https://openalex.org/T11157","wikipedia":"https://en.wikipedia.org/wiki/Chronic_lymphocytic_leukemia"},"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment"},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research"},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders"},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment"},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema"},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments"},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research"},{"id":"https://openalex.org/T13738","display_name":"Congenital Ear and Nasal Anomalies"}],"works_count":57779,"cited_by_count":831090,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11157","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:09"}