{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","description":"This cluster of papers focuses on the biochemistry and molecular cell biology of diabetic complications, particularly exploring the role of Advanced Glycation End Products (AGEs), HMGB1, oxidative stress, inflammation, and the receptor for AGEs (RAGE) in the pathobiology of diabetes. The papers also delve into the involvement of mitochondrial superoxide, toll-like receptors, necrotic cells, and cellular signaling pathways in diabetic complications.","keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.5125},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.6418},{"id":"https://openalex.org/keywords/glycation","display_name":"glycation","score":0.4663},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.3502},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.3612},{"id":"https://openalex.org/keywords/protein-glycation","display_name":"protein glycation","score":0.5474},{"id":"https://openalex.org/keywords/nepsilon-carboxymethyl-lysine","display_name":"carboxymethyllysine","score":0.5926},{"id":"https://openalex.org/keywords/glyoxalase-1","display_name":"glyoxalase I","score":0.3619},{"id":"https://openalex.org/keywords/soluble-receptor-for-advanced-glycation-end-products","display_name":"soluble receptor for advanced glycation end products","score":0.5059},{"id":"https://openalex.org/keywords/pentosidine","display_name":"pentosidine","score":0.4869},{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.2441},{"id":"https://openalex.org/keywords/glycated-albumin","display_name":"glycated albumin","score":0.2121},{"id":"https://openalex.org/keywords/soluble-rage","display_name":"soluble RAGE","score":0.6937},{"id":"https://openalex.org/keywords/skin-autofluorescence","display_name":"skin autofluorescence","score":0.4259},{"id":"https://openalex.org/keywords/glycated-proteins","display_name":"glycated proteins","score":0.3876},{"id":"https://openalex.org/keywords/age-receptor","display_name":"AGE receptor","score":0.7828},{"id":"https://openalex.org/keywords/amadori-products","display_name":"Amadori products","score":0.6203},{"id":"https://openalex.org/keywords/3-deoxyglucosone","display_name":"3-deoxyglucosone","score":0.5123},{"id":"https://openalex.org/keywords/dietary-ages","display_name":"dietary AGEs","score":0.901},{"id":"https://openalex.org/keywords/glycoxidation","display_name":"glycoxidation","score":0.54},{"id":"https://openalex.org/keywords/antiglycation-activity","display_name":"antiglycation activity","score":0.2906},{"id":"https://openalex.org/keywords/age-formation-inhibition","display_name":"AGE formation inhibition","score":0.7537},{"id":"https://openalex.org/keywords/carbonyl-stress","display_name":"carbonyl stress","score":0.3151},{"id":"https://openalex.org/keywords/dicarbonyl-compounds","display_name":"dicarbonyl compounds","score":0.2302},{"id":"https://openalex.org/keywords/age-inhibitors","display_name":"AGE inhibitors","score":0.8119}],"legacy_keywords":"Advanced Glycation End Products; HMGB1; Oxidative Stress; Inflammation; RAGE; Diabetes; Mitochondrial Superoxide; Toll-like Receptors; Necrotic Cells; Cellular Signaling","ids":{"openalex":"https://openalex.org/T11142","wikipedia":"https://en.wikipedia.org/wiki/Complications_of_diabetes_mellitus"},"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders"},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing"},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms"}],"works_count":32511,"cited_by_count":991577,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11142","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:09"}