{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","description":"This cluster of papers explores the genetic, physiological, and environmental influences on sex determination and differentiation in various organisms. It covers topics such as X chromosome inactivation, Y chromosome degeneration, gonadal development, sexually dimorphic gene expression, Turner syndrome, SRY gene function, aromatase expression, Wnt signaling pathway, and temperature-dependent sex determination.","keywords":[{"id":"https://openalex.org/keywords/sex-determination","display_name":"sex determination","score":0.2769},{"id":"https://openalex.org/keywords/turner-syndrome","display_name":"Turner syndrome","score":0.4531},{"id":"https://openalex.org/keywords/sex-chromosomes","display_name":"sex chromosomes","score":0.3547},{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.3192},{"id":"https://openalex.org/keywords/y-chromosome","display_name":"Y chromosome","score":0.2877},{"id":"https://openalex.org/keywords/klinefelter-syndrome","display_name":"Klinefelter syndrome","score":0.2823},{"id":"https://openalex.org/keywords/sex-chromosome-evolution","display_name":"sex chromosome evolution","score":0.6855},{"id":"https://openalex.org/keywords/sexual-differentiation","display_name":"sexual differentiation","score":0.2042},{"id":"https://openalex.org/keywords/sex-chromosome-aneuploidy","display_name":"sex chromosome aneuploidy","score":0.4785},{"id":"https://openalex.org/keywords/sex-chromosome-abnormalities","display_name":"sex chromosome abnormalities","score":0.4693},{"id":"https://openalex.org/keywords/gonadal-dysgenesis","display_name":"gonadal dysgenesis","score":0.4259},{"id":"https://openalex.org/keywords/dosage-compensation","display_name":"dosage compensation","score":0.547},{"id":"https://openalex.org/keywords/sex-reversal","display_name":"sex reversal","score":0.2461},{"id":"https://openalex.org/keywords/sex-determining-genes","display_name":"sex determination genes","score":0.6133},{"id":"https://openalex.org/keywords/sry-gene","display_name":"SRY gene","score":0.4442},{"id":"https://openalex.org/keywords/barr-body","display_name":"sex chromatin","score":0.5271},{"id":"https://openalex.org/keywords/sex-biased-gene-expression","display_name":"sex-biased gene expression","score":0.3677},{"id":"https://openalex.org/keywords/sry","display_name":"SRY","score":0.5558},{"id":"https://openalex.org/keywords/sex-linked-inheritance","display_name":"sex-linked inheritance","score":0.2455},{"id":"https://openalex.org/keywords/temperature-dependent-sex-determination","display_name":"temperature-dependent sex determination","score":0.388},{"id":"https://openalex.org/keywords/gonadal-differentiation","display_name":"gonadal differentiation","score":0.4591},{"id":"https://openalex.org/keywords/sex-linked-genes","display_name":"sex-linked genes","score":0.4635},{"id":"https://openalex.org/keywords/x-linked-genes","display_name":"X-linked genes","score":0.2872},{"id":"https://openalex.org/keywords/dmrt1","display_name":"DMRT1","score":0.483},{"id":"https://openalex.org/keywords/w-chromosome","display_name":"W chromosome","score":0.4408}],"legacy_keywords":"Sex Determination; X Chromosome Inactivation; Y Chromosome Degeneration; Gonadal Development; Sexually Dimorphic Gene Expression; Turner Syndrome; SRY Gene; Aromatase Expression; Wnt Signaling Pathway; Temperature-Dependent Sex Determination","ids":{"openalex":"https://openalex.org/T11077","wikipedia":"https://en.wikipedia.org/wiki/Sex_determination_and_differentiation"},"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure"},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology"},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease"},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology"},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock"},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research"},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior"},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research"},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects"},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer"},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders"},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities"},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies"},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research"},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies"},{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research"},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases"},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals"},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases"},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments"},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics"},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders"},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting"},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia"},{"id":"https://openalex.org/T11974","display_name":"Lepidoptera: Biology and Taxonomy"},{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research"},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases."},{"id":"https://openalex.org/T12370","display_name":"Advances in Cucurbitaceae Research"},{"id":"https://openalex.org/T12447","display_name":"Spider Taxonomy and Behavior Studies"},{"id":"https://openalex.org/T12749","display_name":"Race, Genetics, and Society"},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments"},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders"},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction"},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments"},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health"},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance"},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms"},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease"},{"id":"https://openalex.org/T14333","display_name":"Dermatoglyphics and Human Traits"}],"works_count":49765,"cited_by_count":985417,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11077","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:09"}