{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","description":"This cluster of papers focuses on the molecular mechanisms and treatment strategies for depression, with a particular emphasis on antidepressant medications, ketamine, NMDA receptor antagonists, and neurobiological pathways. It covers topics such as treatment-resistant depression, glutamate signaling, cognitive impairment, and synaptic plasticity. The papers also discuss clinical guidelines and the evaluation of outcomes for various treatment approaches.","keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.2199},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.2445},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.2392},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.4684},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.6604},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.2594},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.2804},{"id":"https://openalex.org/keywords/antidepressant-treatment","display_name":"antidepressant treatment","score":0.3838},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.24},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.5378},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.2284},{"id":"https://openalex.org/keywords/antidepressant-mechanism-of-action","display_name":"antidepressant mechanism","score":0.4883},{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.2794},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.2085},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.2233},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.2081},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.3139},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.2968},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.3201},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":0.2305},{"id":"https://openalex.org/keywords/hamilton-depression-rating-scale","display_name":"Hamilton Depression Rating Scale","score":0.2316},{"id":"https://openalex.org/keywords/melancholic-depression","display_name":"endogenous depression","score":0.3045},{"id":"https://openalex.org/keywords/rapid-acting-antidepressants","display_name":"rapid-acting antidepressants","score":0.8188},{"id":"https://openalex.org/keywords/esketamine","display_name":"esketamine","score":0.431},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":0.2016}],"legacy_keywords":"Depression; Antidepressant; Ketamine; NMDA Receptor; Treatment-Resistant Depression; Neurobiological Mechanisms; Glutamate Signaling; Cognitive Impairment; Synaptic Plasticity; Clinical Guidelines","ids":{"openalex":"https://openalex.org/T11071","wikipedia":"https://en.wikipedia.org/wiki/Management_of_depression"},"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation"},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis"},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research"},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects"},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy"},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications"},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions"},{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts"},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases"},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research"},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment"},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research"},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds"},{"id":"https://openalex.org/T13130","display_name":"Biological and pharmacological studies of plants"},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants"},{"id":"https://openalex.org/T13365","display_name":"Medical and Biological Ozone Research"},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research"},{"id":"https://openalex.org/T13767","display_name":"Leech Biology and Applications"},{"id":"https://openalex.org/T13809","display_name":"Philosophy, Health, and Society"},{"id":"https://openalex.org/T13921","display_name":"Biological Stains and Phytochemicals"},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research"}],"works_count":101774,"cited_by_count":1958261,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T11071","updated_date":"2026-10-18T03:01:31","created_date":"2024-01-23T15:27:09"}