{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","description":"This cluster of papers focuses on the diverse roles of fluorine in medicinal chemistry and pharmaceuticals, including its use in bioisosteres, trifluoromethylation, enantioselective fluorination, PET imaging, and agrochemicals. The papers cover a wide range of topics such as organofluorine chemistry, C\u2013F bond activation, and the introduction of fluorine-containing functional groups.","keywords":[{"id":"https://openalex.org/keywords/organofluorine-compounds","display_name":"organofluorine compounds","score":0.4864},{"id":"https://openalex.org/keywords/organofluorine-synthesis","display_name":"organofluorine synthesis","score":0.7843},{"id":"https://openalex.org/keywords/trifluoromethyl-compounds","display_name":"trifluoromethyl compounds","score":0.427},{"id":"https://openalex.org/keywords/fluorination","display_name":"fluorination","score":0.3356},{"id":"https://openalex.org/keywords/fluorinated-heterocycles","display_name":"fluorinated heterocycles","score":0.445},{"id":"https://openalex.org/keywords/fluorinated-compounds","display_name":"fluorinated compounds","score":0.3076},{"id":"https://openalex.org/keywords/trifluoromethylation","display_name":"trifluoromethylation","score":0.649},{"id":"https://openalex.org/keywords/fluorinated-alkenes","display_name":"fluorinated alkenes","score":0.6044},{"id":"https://openalex.org/keywords/fluorinating-agents","display_name":"fluorinating agents","score":0.6914},{"id":"https://openalex.org/keywords/organofluorine-chemistry","display_name":"organofluorine chemistry","score":0.6799},{"id":"https://openalex.org/keywords/fluorinated-aromatic-compounds","display_name":"fluorinated aromatic compounds","score":0.395},{"id":"https://openalex.org/keywords/fluorinated-amino-acids","display_name":"fluorinated amino acids","score":0.4547},{"id":"https://openalex.org/keywords/electrochemical-fluorination","display_name":"electrochemical fluorination","score":0.7128},{"id":"https://openalex.org/keywords/fluorine-chemistry","display_name":"fluorine chemistry","score":0.401},{"id":"https://openalex.org/keywords/electrophilic-fluorination","display_name":"electrophilic fluorination","score":0.6974},{"id":"https://openalex.org/keywords/c-f-bond-activation","display_name":"C\u2013F bond activation","score":0.3505},{"id":"https://openalex.org/keywords/difluoromethylation","display_name":"difluoromethylation","score":0.7673},{"id":"https://openalex.org/keywords/selectfluor","display_name":"Selectfluor","score":0.5031},{"id":"https://openalex.org/keywords/c-f-bond-formation","display_name":"C\u2013F bond formation","score":0.567},{"id":"https://openalex.org/keywords/difluorocarbene","display_name":"difluorocarbene","score":0.7206},{"id":"https://openalex.org/keywords/trifluoromethyl-ketones","display_name":"trifluoromethyl ketones","score":0.4447},{"id":"https://openalex.org/keywords/fluorinated-hydrocarbons","display_name":"fluorinated hydrocarbons","score":0.2022},{"id":"https://openalex.org/keywords/perfluoroalkylation","display_name":"perfluoroalkylation","score":0.6109},{"id":"https://openalex.org/keywords/perfluoroalkyl-iodides","display_name":"perfluoroalkyl iodides","score":0.5376},{"id":"https://openalex.org/keywords/trifluoromethylthiolation","display_name":"trifluoromethylthiolation","score":0.6971}],"legacy_keywords":"Fluorine; Medicinal Chemistry; Pharmaceuticals; Bioisosteres; Trifluoromethylation; Organofluorine Chemistry; C\u2013F Bond Activation; Enantioselective Fluorination; PET Imaging; Agrochemicals","ids":{"openalex":"https://openalex.org/T10947","wikipedia":"https://en.wikipedia.org/wiki/Fluorine_in_medicinal_chemistry"},"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems"},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery"},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems"},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes"}],"works_count":65472,"cited_by_count":867278,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10947","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:08"}