{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","description":"This cluster of papers focuses on the use of HER2-targeted therapies, such as trastuzumab and pertuzumab, in the treatment of HER2-positive breast cancer. It explores the mechanisms of action, resistance, and combination therapies involving chemotherapy and monoclonal antibodies. The cluster also delves into the role of EGFR, neuregulin 1, and ADAM metalloproteinases in HER2 signaling and breast cancer progression.","keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.3979},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.4028},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.256},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.2091},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.5136},{"id":"https://openalex.org/keywords/her2-amplification","display_name":"HER2 amplification","score":0.5427},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.4792},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":0.6123},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.3144},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.3809},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.3022},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.4477},{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.6956},{"id":"https://openalex.org/keywords/trastuzumab-emtansine","display_name":"trastuzumab emtansine","score":0.5495},{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":0.4829},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.2803},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.2425},{"id":"https://openalex.org/keywords/erbb-receptors","display_name":"ErbB receptors","score":0.5598},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":0.3726},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.3155},{"id":"https://openalex.org/keywords/her2-low-breast-cancer","display_name":"HER2-low breast cancer","score":0.6207},{"id":"https://openalex.org/keywords/her2-positive-metastatic-breast-cancer","display_name":"HER2-positive metastatic breast cancer","score":0.7874},{"id":"https://openalex.org/keywords/neratinib","display_name":"neratinib","score":0.5002},{"id":"https://openalex.org/keywords/her2-testing","display_name":"HER2 testing","score":0.5712},{"id":"https://openalex.org/keywords/bt474-cells","display_name":"BT474 cells","score":0.2918}],"legacy_keywords":"HER2; breast cancer; trastuzumab; EGFR; monoclonal antibody; chemotherapy; metastatic; receptor tyrosine kinases; neuregulin 1; ADAM metalloproteinases","ids":{"openalex":"https://openalex.org/T10755","wikipedia":"https://en.wikipedia.org/wiki/HER2"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms"},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research"},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":59712,"cited_by_count":1361777,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10755","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:08"}