{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","description":"This cluster of papers explores the multifaceted roles of matrix metalloproteinases (MMPs) in cancer progression, angiogenesis, inflammation regulation, and extracellular matrix remodeling. It also delves into the potential of MMPs as therapeutic targets for cancer therapy and their involvement in various physiological processes such as cell signaling and tissue remodeling.","keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.2332},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.2015},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.3049},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.2028},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.3658},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.3106},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.4886},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.2439},{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.2761},{"id":"https://openalex.org/keywords/mt1-mmp","display_name":"MT1-MMP","score":0.5308},{"id":"https://openalex.org/keywords/aspartic-protease","display_name":"aspartic protease","score":0.2093},{"id":"https://openalex.org/keywords/protease-inhibition","display_name":"protease inhibition","score":0.2517},{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":0.2701},{"id":"https://openalex.org/keywords/cysteine-protease-inhibitors","display_name":"cysteine protease inhibitors","score":0.3204},{"id":"https://openalex.org/keywords/serpins","display_name":"serpins","score":0.3063},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.3157},{"id":"https://openalex.org/keywords/gelatinase","display_name":"gelatinase","score":0.2869},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.2583},{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":0.2246},{"id":"https://openalex.org/keywords/upar","display_name":"uPAR","score":0.3334},{"id":"https://openalex.org/keywords/timp-3","display_name":"TIMP-3","score":0.2395},{"id":"https://openalex.org/keywords/trypsin-inhibition","display_name":"trypsin inhibition","score":0.3096},{"id":"https://openalex.org/keywords/zymogen-activation","display_name":"zymogen activation","score":0.3405},{"id":"https://openalex.org/keywords/mmp-inhibition","display_name":"matrix metalloproteinase inhibition","score":0.2615},{"id":"https://openalex.org/keywords/urokinase-receptor","display_name":"urokinase receptor","score":0.447}],"legacy_keywords":"Matrix Metalloproteinases; Tissue Inhibitors of Metalloproteinases; Cancer Progression; Angiogenesis; Extracellular Matrix Remodeling; Protease Inhibition; Inflammation Regulation; Cell Signaling; Metastasis; Extracellular Matrix","ids":{"openalex":"https://openalex.org/T10620","wikipedia":"https://en.wikipedia.org/wiki/Matrix_metalloproteinase"},"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation"},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies"},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment"},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research"},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism"},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics"},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies"},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways"},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism"},{"id":"https://openalex.org/T13350","display_name":"Myxozoan Parasites in Aquatic Species"},{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies"},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity"}],"works_count":91955,"cited_by_count":2523156,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10620","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:07"}