{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","description":"This cluster of papers focuses on the p53 signaling network, exploring its role in cell cycle regulation, tumor suppression, cancer therapy, apoptosis, and the impact of mutations. The papers cover various aspects of p53-MDM2 interaction, cyclin-dependent kinases, and the intricate mechanisms of p53 regulation in the context of cancer research.","keywords":[{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.4191},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.274},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.2618},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.2499},{"id":"https://openalex.org/keywords/mutant-p53","display_name":"mutant p53","score":0.5128},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.2069},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.2782},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.2181},{"id":"https://openalex.org/keywords/p73","display_name":"p73","score":0.409},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.2054},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.2215},{"id":"https://openalex.org/keywords/p53-stabilization","display_name":"p53 stabilization","score":0.5193},{"id":"https://openalex.org/keywords/e2f-transcription-factors","display_name":"E2F transcription factors","score":0.3561},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.3783},{"id":"https://openalex.org/keywords/wild-type-p53","display_name":"wild-type p53","score":0.4479},{"id":"https://openalex.org/keywords/p53-target-genes","display_name":"p53 target genes","score":0.5755},{"id":"https://openalex.org/keywords/cyclin-a","display_name":"cyclin A","score":0.2391},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.5032},{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.2456},{"id":"https://openalex.org/keywords/rb-phosphorylation","display_name":"retinoblastoma protein phosphorylation","score":0.2321},{"id":"https://openalex.org/keywords/p53-family","display_name":"p53 family","score":0.5745},{"id":"https://openalex.org/keywords/p53-gene","display_name":"p53 gene","score":0.3376},{"id":"https://openalex.org/keywords/p53-mdm2-interaction","display_name":"p53-MDM2 interaction","score":0.6021},{"id":"https://openalex.org/keywords/li-fraumeni-syndrome","display_name":"Li-Fraumeni syndrome","score":0.2268},{"id":"https://openalex.org/keywords/p53-reactivation","display_name":"p53 reactivation","score":0.6663}],"legacy_keywords":"p53; cell cycle; MDM2; tumor suppression; cancer therapy; apoptosis; CDKs; mutation; regulation; oncogene","ids":{"openalex":"https://openalex.org/T10583","wikipedia":"https://en.wikipedia.org/wiki/P53"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research"},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":81523,"cited_by_count":2773608,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10583","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:07"}