{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","description":"This cluster of papers explores the mechanisms of multidrug resistance in cancer, focusing on the role of ATP-dependent transporters, P-glycoprotein, bile acids, ABC transporters, and drug efflux pumps. It also delves into the involvement of nuclear receptors, metabolic regulation, and the impact on intestinal barrier function.","keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.5469},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.3902},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.6744},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.4853},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.4791},{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.492},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.263},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.5933},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.5899},{"id":"https://openalex.org/keywords/multidrug-resistance-reversal","display_name":"multidrug resistance reversal","score":0.6785},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.2251},{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.3376},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.3999},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.4188},{"id":"https://openalex.org/keywords/multidrug-resistance-protein","display_name":"multidrug resistance protein","score":0.65},{"id":"https://openalex.org/keywords/abcb1-gene","display_name":"MDR1 gene","score":0.6027},{"id":"https://openalex.org/keywords/multidrug-resistance-associated-protein","display_name":"multidrug resistance-associated protein","score":0.7389},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.2327},{"id":"https://openalex.org/keywords/organic-anion-transporters","display_name":"organic anion transporters","score":0.6632},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.2199},{"id":"https://openalex.org/keywords/bile-acid-transport","display_name":"bile acid transport","score":0.6625},{"id":"https://openalex.org/keywords/organic-anion-transporting-polypeptides","display_name":"organic anion transporting polypeptides","score":0.6916},{"id":"https://openalex.org/keywords/p-glycoprotein-inhibitors","display_name":"P-glycoprotein inhibitors","score":0.652},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.5566},{"id":"https://openalex.org/keywords/organic-cation-transporters","display_name":"organic cation transporters","score":0.6195}],"legacy_keywords":"Multidrug Resistance; ATP-dependent Transporters; P-glycoprotein; Bile Acids; ABC Transporters; Drug Efflux Pumps; Nuclear Receptors; Cancer Chemotherapy; Metabolic Regulation; Intestinal Barrier","ids":{"openalex":"https://openalex.org/T10570","wikipedia":"https://en.wikipedia.org/wiki/Multidrug_resistance"},"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers"},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties"},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care"},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research"},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments"},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis"},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management"},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection"},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening"},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways"},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders"},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research"},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies"},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments"},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts"},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis"},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases"},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research"},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions"},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling"},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology"},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases"},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy"},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors"},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections"},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas"},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies"},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis"},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies"},{"id":"https://openalex.org/T13434","display_name":"Cancer Research and Treatment"},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors"},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology"}],"works_count":89791,"cited_by_count":2314196,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10570","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:07"}