{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","description":"This cluster of papers explores the genetic, clinical, and epidemiological aspects of hemoglobin disorders, including sickle-cell disease and thalassemia. It covers topics such as hemolysis, fetal hemoglobin regulation, iron overload, pulmonary hypertension, and the use of transfusion therapy. The genetic regulation of erythropoiesis by factors like GATA1 and BCL11A is also a focus of several papers.","keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.695},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.7479},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.7632},{"id":"https://openalex.org/keywords/thalassemia","display_name":"thalassemia","score":0.6138},{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.7131},{"id":"https://openalex.org/keywords/vaso-occlusive-crisis","display_name":"vaso-occlusive crisis","score":0.8575},{"id":"https://openalex.org/keywords/fetal-hemoglobin","display_name":"fetal hemoglobin","score":0.6794},{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.6682},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.296},{"id":"https://openalex.org/keywords/alpha-thalassemia","display_name":"alpha-thalassemia","score":0.8573},{"id":"https://openalex.org/keywords/hemoglobin-s","display_name":"hemoglobin S","score":0.8078},{"id":"https://openalex.org/keywords/beta-thalassemia-major","display_name":"beta-thalassemia major","score":0.7815},{"id":"https://openalex.org/keywords/thalassemia-major","display_name":"thalassemia major","score":0.725},{"id":"https://openalex.org/keywords/hemoglobin-electrophoresis","display_name":"hemoglobin electrophoresis","score":0.7927},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.8707},{"id":"https://openalex.org/keywords/beta-globin-gene-mutations","display_name":"beta-globin gene mutations","score":0.9208},{"id":"https://openalex.org/keywords/beta-globin-gene","display_name":"beta-globin gene","score":0.6142},{"id":"https://openalex.org/keywords/iron-chelation-therapy","display_name":"iron chelation therapy","score":0.4859},{"id":"https://openalex.org/keywords/beta-thalassemia-trait","display_name":"beta-thalassemia trait","score":0.8111},{"id":"https://openalex.org/keywords/hemoglobin-a2","display_name":"hemoglobin A2","score":0.8524},{"id":"https://openalex.org/keywords/hemoglobin-e","display_name":"hemoglobin E","score":0.8328},{"id":"https://openalex.org/keywords/vessel-occlusion","display_name":"vascular occlusion","score":0.2177},{"id":"https://openalex.org/keywords/transfusion-dependent-thalassemia","display_name":"transfusion-dependent thalassemia","score":0.8027},{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.4143},{"id":"https://openalex.org/keywords/hemoglobin-c","display_name":"hemoglobin C","score":0.7301}],"legacy_keywords":"Sickle-cell Disease; Thalassemia; Hemolysis; Fetal Hemoglobin; Iron Overload; Genetic Regulation; Pulmonary Hypertension; Transfusion Therapy; GATA Factor; Epidemiology","ids":{"openalex":"https://openalex.org/T10554","wikipedia":"https://en.wikipedia.org/wiki/Hemoglobinopathy"},"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment"},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research"},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research"},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment"},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema"},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments"},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research"},{"id":"https://openalex.org/T13738","display_name":"Congenital Ear and Nasal Anomalies"}],"works_count":115179,"cited_by_count":1383056,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10554","updated_date":"2026-10-18T03:01:31","created_date":"2024-01-23T15:27:07"}