{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","description":"This cluster of papers focuses on the reciprocal developmental pathways for the generation of pathogenic effector TH17 cells and regulatory T cells, particularly in the context of autoimmune inflammation, interleukin-23, psoriasis, and the role of cytokines such as TGF-\u00df. It also explores the differentiation, cytokine profile, and function of human interleukin 17\u2013producing helper T cells.","keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.5419},{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.7982},{"id":"https://openalex.org/keywords/psoriasis-treatment","display_name":"psoriasis treatment","score":0.8037},{"id":"https://openalex.org/keywords/ustekinumab","display_name":"ustekinumab","score":0.3228},{"id":"https://openalex.org/keywords/secukinumab","display_name":"secukinumab","score":0.4721},{"id":"https://openalex.org/keywords/moderate-to-severe-psoriasis","display_name":"moderate-to-severe psoriasis","score":0.9658},{"id":"https://openalex.org/keywords/psoriasis-pathogenesis","display_name":"psoriasis pathogenesis","score":0.929},{"id":"https://openalex.org/keywords/pasi","display_name":"PASI","score":0.7167},{"id":"https://openalex.org/keywords/dermatology-life-quality-index","display_name":"Dermatology Life Quality Index","score":0.3142},{"id":"https://openalex.org/keywords/pasi-score","display_name":"PASI score","score":0.8217},{"id":"https://openalex.org/keywords/acitretin","display_name":"acitretin","score":0.4568},{"id":"https://openalex.org/keywords/generalized-pustular-psoriasis","display_name":"generalized pustular psoriasis","score":0.8415},{"id":"https://openalex.org/keywords/pediatric-psoriasis","display_name":"pediatric psoriasis","score":0.8787},{"id":"https://openalex.org/keywords/il-23-inhibitors","display_name":"IL-23 inhibitors","score":0.6016},{"id":"https://openalex.org/keywords/ixekizumab","display_name":"ixekizumab","score":0.6211},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.2555},{"id":"https://openalex.org/keywords/psoriasis-area-and-severity-index","display_name":"Psoriasis Area and Severity Index","score":0.8159},{"id":"https://openalex.org/keywords/nail-psoriasis","display_name":"nail psoriasis","score":0.5371},{"id":"https://openalex.org/keywords/il-17-inhibitors","display_name":"IL-17 inhibitors","score":0.4748},{"id":"https://openalex.org/keywords/calcipotriol","display_name":"calcipotriol","score":0.507},{"id":"https://openalex.org/keywords/psoriasis-severity","display_name":"psoriasis severity","score":0.792},{"id":"https://openalex.org/keywords/pustular-psoriasis","display_name":"pustular psoriasis","score":0.6272},{"id":"https://openalex.org/keywords/apremilast","display_name":"apremilast","score":0.4134},{"id":"https://openalex.org/keywords/guselkumab","display_name":"guselkumab","score":0.5244},{"id":"https://openalex.org/keywords/scalp-psoriasis","display_name":"scalp psoriasis","score":0.7604}],"legacy_keywords":"IL-17; TH17 Cells; Interleukin-23; Autoimmune Inflammation; Psoriasis; TGF-\u00df; Regulatory T Cells; Inflammatory Cytokines; Pathogenic Effector Cells; Immune System","ids":{"openalex":"https://openalex.org/T10469","wikipedia":"https://en.wikipedia.org/wiki/TH17_cell"},"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology"},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation"},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota"},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses"},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases"},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction"},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer"},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine"},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms"},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy"},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms"},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses"},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders"},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies"},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods"},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology"},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins"},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways"},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation"},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases"},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor"},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations"},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses"},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways"},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms"}],"works_count":88799,"cited_by_count":1391686,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10469","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:06"}