{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","description":"This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.","keywords":[{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4954},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.5436},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.3582},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.2568},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.5137},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.4174},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.5964},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.7785},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.3031},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.7544},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.4802},{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.6997},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.6083},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.5969},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.3693},{"id":"https://openalex.org/keywords/udp-glucuronosyltransferase","display_name":"UDP-glucuronosyltransferase","score":0.6012},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.3966},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.3411},{"id":"https://openalex.org/keywords/drug-response-variability","display_name":"drug response variability","score":0.5397},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.7045},{"id":"https://openalex.org/keywords/pharmacogenetic-testing","display_name":"pharmacogenetic testing","score":0.7756},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.6604},{"id":"https://openalex.org/keywords/cyp3a5","display_name":"CYP3A5","score":0.7325},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.3683},{"id":"https://openalex.org/keywords/hepatic-drug-metabolism","display_name":"hepatic drug metabolism","score":0.6127}],"legacy_keywords":"Cytochrome P450; Pharmacogenetics; Drug Metabolism; Genetic Variation; Enzyme Activities; Pharmacokinetics; Polymorphisms; Personalized Medicine; Warfarin Dose; Xenobiotic Metabolism","ids":{"openalex":"https://openalex.org/T10375","wikipedia":"https://en.wikipedia.org/wiki/Drug_metabolism"},"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection"},{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare"},{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research"},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology"},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds"},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies"},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research"},{"id":"https://openalex.org/T13322","display_name":"Hibiscus Plant Research Studies"},{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies"},{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications"},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices"},{"id":"https://openalex.org/T14108","display_name":"Medical and Pharmaceutic Studies"},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research"},{"id":"https://openalex.org/T14360","display_name":"Psidium guajava Extracts and Applications"}],"works_count":199934,"cited_by_count":3841879,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10375","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:06"}