{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","description":"This cluster of papers focuses on the development, function, and regulation of regulatory T cells (Tregs), particularly emphasizing the role of transcription factor Foxp3, TGF-\u00df induction, immune tolerance, thymic selection, memory T cells, IL-2 signaling, and their involvement in tumor immunity and immunological surveillance. The cluster also explores the implications of Tregs in autoimmunity and their potential for therapeutic interventions.","keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.273},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.2754},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.2639},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.6296},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.266},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.3038},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.3462},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.4964},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.4847},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.4564},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.3922},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.4768},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.3753},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.5008},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.2951},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.3533},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.3439},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.2823},{"id":"https://openalex.org/keywords/t-cell-tolerance","display_name":"T cell tolerance","score":0.5556},{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.4568},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.3627},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.3061},{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.5356},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.8069},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.2982}],"legacy_keywords":"Foxp3; TGF-\u00df; CD4+CD25+; Immune Tolerance; Autoimmunity; Thymic Selection; Memory T Cells; IL-2; Tumor Immunity; Immunological Surveillance","ids":{"openalex":"https://openalex.org/T10031","wikipedia":"https://en.wikipedia.org/wiki/Regulatory_T_cell"},"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation"},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis"},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota"},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses"},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases"},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction"},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer"},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine"},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms"},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy"},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms"},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses"},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders"},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies"},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods"},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology"},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins"},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways"},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation"},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases"},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor"},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations"},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses"},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways"},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms"}],"works_count":261863,"cited_by_count":7653691,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T10031","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:05"}