{"id":"https://openalex.org/G9800568","display_name":"Molecular Mechanisms of UBE3A Mediated Synapse Development in Angelman Syndrome","description":"PUBLIC HEALTH RELEVANCE: The proposed studies are designed to understand at the molecular level the functions and regulation of the ubiquitin ligase, UBE3A, in the context of synapse biogenesis and Angelman Syndrome etiology. The successful completion of this work will provide new insights into the molecular mechanisms of UBE3A substrates in the brain. Given the high prevalence between cytogenetic abnormalities associated with the UBE3A gene and cognitive disorders, any advancement in our understanding of the molecular mechanisms mediating UBE3A dependent brain development promises to improve pharmacological approaches for the treatment of individuals with cognitive impairment.","funder_award_id":"R01MH102364","funder":{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","doi":"10.13039/100000025"},"funded_outputs":["https://openalex.org/W29979964","https://openalex.org/W1752412230","https://openalex.org/W2597217272","https://openalex.org/W2600938528","https://openalex.org/W2856333867","https://openalex.org/W2903563683","https://openalex.org/W2917865535","https://openalex.org/W3192696049","https://openalex.org/W3202970859"],"funded_outputs_count":9,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2014-06-16","end_date":"2020-02-29","start_year":2014,"end_year":2020,"landing_page_url":"https://reporter.nih.gov/project-details/8759291","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"SETH S","family_name":"MARGOLIS","orcid":null,"role_start":null,"affiliation":{"name":"JOHNS HOPKINS UNIVERSITY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G9800568","primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9944,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9944,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}