{"id":"https://openalex.org/G9000888317","display_name":"hHv1 channels in neutrophils and the innate immune inflammatory response","description":"NARRATIVE (General Audience, public health relevance, 2-3 sentences) This research addresses a specific unmet medical need, the absence of an effective medical therapy for acute lung injury (ALI), a common disorder in patients with bacterial pneumonia or SARS-CoV-2 infec- tion and its severe form, acute respiratory distress syndrome (ARDS) that is fatal in 40% of patients. The work is broadly impactful because the white blood cells called neutrophils (Polymorphonuclear leuko- cytes, PMN) that damage the lungs in infectious ALI/ARDS also cause other acute and chronic inflam- matory diseases. In the last period, we showed that the human voltage-gated proton channel (hHv1) in PMN is essential to produce the inflammatory response, and we propose here to confront lung injury by a novel strategy: targeting hHv1 in PMN, both directly and by blocking a natural activator of hHv1, al- bumin (Alb), that we recently reported to be required for hHv1 operation, thereby offering two ways to confront the disease at the earliest stage before it becomes a more complex disorder.","funder_award_id":"R01HL159711","funder":{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","doi":"10.13039/100000050"},"funded_outputs":["https://openalex.org/W4281692303","https://openalex.org/W4313219371","https://openalex.org/W4386466887","https://openalex.org/W4389828790","https://openalex.org/W4402904355","https://openalex.org/W4404633153","https://openalex.org/W4415479115","https://openalex.org/W4416785793","https://openalex.org/W7133339266","https://openalex.org/W7208725382"],"funded_outputs_count":10,"parent_awards":[],"sub_awards":[{"asserted_by":"funder","funder":{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine"},"relationship":"sub_award","display_name":"hHv1 channels in neutrophils and the innate immune inflammatory response (sub-award to UNIVERSITY OF CHICAGO)","id":"https://openalex.org/G9001234590"}],"sub_awards_count":1,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2022-08-05","end_date":"2027-06-30","start_year":2022,"end_year":2027,"landing_page_url":"https://reporter.nih.gov/project-details/10677676","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"STEVE A N","family_name":"GOLDSTEIN","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITY OF CALIFORNIA-IRVINE","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G9000888317","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"updated_date":"2026-10-31T03:01:04.000Z","created_date":"2026-10-09T19:56:01.000Z"}