{"id":"https://openalex.org/G9000856430","display_name":"Clinical and functional assessment of glaucoma-associated mitochondrial gene variants to facilitate precision eye care","description":"Genetic studies involving thousands of individuals have identified many genes associated with glaucoma risk, though this has not yet translated to personalized approaches for diagnosis, monitoring or treatment of this common, blinding disease. This mentored clinician-scientist career development proposal will investigate the clinical impact and underlying disease mechanisms for glaucoma-associated genes that function in the mitochondria, the energy-producing parts of our cells. The approach is designed to help pave the way for personalized glaucoma care for individuals whose disease is driven by mitochondrial gene variants; the methodologies employed in this proposal can also be readily applied to other genes and pathways in the future to lay the foundation for precision glaucoma care.","funder_award_id":"K23EY035734","funder":{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","doi":"10.13039/100000053"},"funded_outputs":["https://openalex.org/W4406607239","https://openalex.org/W4411965486","https://openalex.org/W4416293232","https://openalex.org/W7125814579","https://openalex.org/W7133200935","https://openalex.org/W7165633621"],"funded_outputs_count":6,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"career_development","funder_scheme":"K23","start_date":"2023-12-01","end_date":"2028-11-30","start_year":2023,"end_year":2028,"landing_page_url":"https://reporter.nih.gov/project-details/10785635","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"INAS F.","family_name":"ABOOBAKAR","orcid":null,"role_start":null,"affiliation":{"name":"MASSACHUSETTS EYE AND EAR INFIRMARY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G9000856430","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]}],"updated_date":"2026-10-29T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}