{"id":"https://openalex.org/G9000856425","display_name":"Linking genome variation to transcriptional network dynamics in human B cells","description":"B cells of the immune system are a leading model for the analysis of gene regulatory networks (GRNs), and variation in the human B cell regulatory genome has been associated with autoimmune diseases and differential vaccine responses. However, there has not been a comprehensive attempt to delineate the cis-regulome of primary human B cells in their resting, activated and terminally differentiated states or to assemble corresponding dynamic GRNs. Based on our recent success in assembling the first comprehensive murine B cell cis-regulome, our inter-disciplinary team is proposing to assemble a human B cell cis-regulome and corresponding dynamic GRNs, and study the consequences of disease-associated non-coding variation in the context of these dynamic GRNs.","funder_award_id":"U01HG012041","funder":{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","doi":"10.13039/100000051"},"funded_outputs":["https://openalex.org/W4281565387","https://openalex.org/W4312082462","https://openalex.org/W4385327577","https://openalex.org/W4389816366","https://openalex.org/W4391931640","https://openalex.org/W4402220283","https://openalex.org/W4404067571","https://openalex.org/W4409154789","https://openalex.org/W4409502882","https://openalex.org/W4409823738","https://openalex.org/W4412422074","https://openalex.org/W4412692505","https://openalex.org/W4413475623","https://openalex.org/W4417123051","https://openalex.org/W7118196334","https://openalex.org/W7128595278","https://openalex.org/W7159392389","https://openalex.org/W7163665735","https://openalex.org/W7167838083","https://openalex.org/W7170064700","https://openalex.org/W7214240432"],"funded_outputs_count":21,"parent_awards":[],"sub_awards":[{"asserted_by":"funder","funder":{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh"},"display_name":"Linking genome variation to transcriptional network dynamics in human B cells (sub-award to THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM)","id":"https://openalex.org/G9001196489","relationship":"sub_award"}],"sub_awards_count":1,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"cooperative_agreement","funder_scheme":"U01","start_date":"2021-08-19","end_date":"2026-05-31","start_year":2021,"end_year":2026,"landing_page_url":"https://reporter.nih.gov/project-details/11118852","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"JISHNU","family_name":"DAS","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITY OF PITTSBURGH AT PITTSBURGH","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G9000856425","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"updated_date":"2026-11-06T00:38:11.000Z","created_date":"2026-10-09T19:56:01.000Z"}