{"id":"https://openalex.org/G856411980","display_name":"Pathogenic monocyte response to chronic lung inflammation in cystic fibrosis","description":"PROJECT NARRATIVE Researchers still do not understand the mechanisms behind the progressive and irreversible lung damage that ultimately causes respiratory failure in patients with cystic fibrosis (CF). Our proposed research aims to identify the mechanisms that drive this progressive lung deterioration in CF. Ultimately, our goal is to identify potential therapeutic targets that, in conjunction with the current CFTR modulator therapies, will help prevent progressive lung tissue damage in CF patients.","funder_award_id":"5r01hl157776-03","funder":{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","doi":"10.13039/100000002"},"funded_outputs":["https://openalex.org/W4404868366"],"funded_outputs_count":1,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":756246.0,"currency":"USD","amount_usd":756246.0,"amount_usd_basis":"usd_native","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2022-01-01","end_date":"2025-11-30","start_year":2022,"end_year":2025,"landing_page_url":"https://reporter.nih.gov/project-details/10745708","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"EMANUELA MARINA","family_name":"BRUSCIA","orcid":null,"role_start":null,"affiliation":{"name":"YALE UNIVERSITY","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G856411980","primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9699,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9699,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}