{"id":"https://openalex.org/G8317808608","display_name":"Holographic imprinting of novelty detection in mice","description":"PROJECT NARRATIVE  Patients with schizophrenia show deficits of elementary sensory processing, affecting their ability of automatic focusing and interact with the changing environment. We will use state of the art methods to record the activity of hundreds of neurons from the mouse cortex, and simultaneously use holographic optogenetics to manipulate the ongoing activity and control behavior output. Finally we will use a holographic imprinting of stimulus evoked activity in a mouse model of schizophrenia to improve the neuronal population activity and attempt to rescue the disease phenotype","funder_award_id":"F31MH122137","funder":{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","doi":"10.13039/100000025"},"funded_outputs":["https://openalex.org/W3149701525","https://openalex.org/W4386601769","https://openalex.org/W4407320352","https://openalex.org/W6892389534","https://openalex.org/W7204494996"],"funded_outputs_count":5,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"fellowship","funder_scheme":"F31","start_date":"2019-09-16","end_date":"2022-09-15","start_year":2019,"end_year":2022,"landing_page_url":"https://reporter.nih.gov/project-details/10023434","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"YURIY","family_name":"SHYMKIV","orcid":null,"role_start":null,"affiliation":{"name":"COLUMBIA UNIV NEW YORK MORNINGSIDE","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G8317808608","primary_topic":{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.5445,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.5445,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"updated_date":"2026-11-03T03:01:00.000Z","created_date":"2026-10-09T19:56:01.000Z"}