{"id":"https://openalex.org/G8317043609","display_name":"Regulation of PMP22 Expression in Peripheral Nerve","description":"PUBLIC HEALTH RELEVANCE: One of the most common inherited diseases affecting the nervous system is Charcot-Marie- Tooth disease, affecting approximately 1 in 3000 individuals. The most common cause of this disease is a duplication of the PMP22 gene (resulting in CMT1A). This proposal is designed to elucidate the mechanism of PMP22 regulation to enable identification of mechanistic targets of potential therapies for CMT1A.","funder_award_id":"R01NS083841","funder":{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","doi":"10.13039/100000065"},"funded_outputs":["https://openalex.org/W2316947309","https://openalex.org/W2409621269","https://openalex.org/W2415781642","https://openalex.org/W2480652978","https://openalex.org/W2550189868","https://openalex.org/W2550373032","https://openalex.org/W2774391451","https://openalex.org/W2804588363","https://openalex.org/W2977879691","https://openalex.org/W3021694533","https://openalex.org/W3084014201","https://openalex.org/W4389024390"],"funded_outputs_count":12,"parent_awards":[],"sub_awards":[{"funder":{"display_name":"University of Wisconsin System","id":"https://openalex.org/F5055504421"},"relationship":"sub_award","asserted_by":"funder","display_name":"Regulation of PMP22 Expression in Peripheral Nerve (sub-award to REGENTS OF THE UNIVERSITY OF MICHIGAN)","id":"https://openalex.org/G9001193494"}],"sub_awards_count":1,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"2014-06-15","end_date":"2020-05-31","start_year":2014,"end_year":2020,"landing_page_url":"https://reporter.nih.gov/project-details/9069615","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"JOHN P","family_name":"SVAREN","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITY OF WISCONSIN-MADISON","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G8317043609","primary_topic":{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.991,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.991,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"updated_date":"2026-10-31T03:01:04.000Z","created_date":"2026-10-09T19:56:01.000Z"}