{"id":"https://openalex.org/G7997313499","display_name":"Inflammatory response regulation by immune system specific autophagy regulator Rufy4","description":"To elucidate the pathophysiological function of immune system-specific autophagy regulator Rufy4 which is constantly expressed in neutrophil, we investigated the involvement of Rufy4 in NETosis progression. Non-inflammatory neutrophils are isolated from wild type, or rufy4-deficient mice peritoneal wash by density-gradient centrifugation. Although NETosis was induced both in wild type and rufy4 deficient neutrophils, NETs expelled from rufy4 KO neutrophil was drastically reduced as compared to wild type. This result suggested that Rufy4 has a critical role in NETosis progression, but not in initiation.","funder_award_id":"18K06937","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W3014127903","https://openalex.org/W3090320429","https://openalex.org/W3135716486","https://openalex.org/W3135943973","https://openalex.org/W3143362050"],"funded_outputs_count":5,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4550000.0,"currency":"JPY","amount_usd":42745.37,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2018-04-01","end_date":"2021-03-31","start_year":2018,"end_year":2021,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K06937/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Seigo","family_name":"TERAWAKI","orcid":null,"role_start":null,"affiliation":{"name":"Osaka City University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000060437217","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5076987202","display_name":"Seigo Terawaki","orcid":"https://orcid.org/0000-0001-6019-1628"},"institutions":[]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G7997313499","primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7822,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7822,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"updated_date":"2026-11-10T03:01:11.000Z","created_date":"2026-07-13T04:17:19.000Z"}