{"id":"https://openalex.org/G7996723219","display_name":"Screening for modulators of Tat positive feedback for biasing HIV latency","description":"PUBLIC HEALTH RELEVANCE: In biological systems, coupled regulatory mechanisms often control the dynamics of fate decisions and their resulting phenotype. In HIV-1 transcriptional feedback these mechanisms contribute fluctuations in gene expression, or `noise' causing diverse levels in gene products and phenotypic diversity. This project aims to exploit noise analysis and drug screening to identify feedback modulators to bias viral decision-making.","funder_award_id":"K22AI120746","funder":{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","doi":"10.13039/100000060"},"funded_outputs":["https://openalex.org/W1863332503","https://openalex.org/W2610834732","https://openalex.org/W2799616637","https://openalex.org/W2905799241","https://openalex.org/W2951941730","https://openalex.org/W3031562564","https://openalex.org/W3133520177","https://openalex.org/W3134700426","https://openalex.org/W3173051677","https://openalex.org/W3189725990","https://openalex.org/W6903539685"],"funded_outputs_count":11,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"career_development","funder_scheme":"K22","start_date":"2015-08-07","end_date":"2017-07-31","start_year":2015,"end_year":2017,"landing_page_url":"https://reporter.nih.gov/project-details/8993556","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"ROY DAVID","family_name":"DAR","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN","country":"UNITED STATES","ids":null}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G7996723219","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"updated_date":"2026-10-29T03:01:01.000Z","created_date":"2026-10-09T19:56:01.000Z"}