{"id":"https://openalex.org/G7995963098","display_name":"Investigation of pathogenic mechanisms for central post-stroke pain and its accompanying emotional disorder - evaluation of microglial activation hypothesis","description":"In this study, we have established experimental conditions that enabled us to measure both stable mechanical withdrawal thresholds of hindpaws and emotional behaviors of thalamic hemorrhage-induced central post-stroke pain model mice. We found that systemic administration of inhibitors for microglial activation including minocycline and p38 MAP kinase inhibitors significantly alleviated the expression of both thalamic hemorrhage-induced mechanical allodynia and increased locomotor activity. Furthermore, N-type voltage-gated Ca channels were suggested to contribute to the development of the thalamic hemorrhage-induced mechanical allodynia in the acute phase. In contrast, we have not yet detected significant thalamic hemorrhage-induced depression-like behaviors in both acute and subacute phases. Thus, further study is necessary for the detection of the depression-like behaviors.","funder_award_id":"15K10311","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W2724306178","https://openalex.org/W2739246125","https://openalex.org/W2741371876","https://openalex.org/W2792717414","https://openalex.org/W2922294599","https://openalex.org/W2996534273","https://openalex.org/W3002338600","https://openalex.org/W7047296758"],"funded_outputs_count":8,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4810000.0,"currency":"JPY","amount_usd":40012.03,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2015-04-01","end_date":"2018-03-31","start_year":2015,"end_year":2018,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K10311/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Kazunori","family_name":"ARITA","orcid":null,"role_start":null,"affiliation":{"name":"Kagoshima University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000090212646","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5064804724","display_name":"Kazunori Arita","orcid":"https://orcid.org/0000-0002-6192-048X"},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G7995963098","primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.5664,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.5664,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"institution_awarded":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-07-13T04:17:19.000Z"}