{"id":"https://openalex.org/G7990360842","display_name":"A novel toxic effect of superantigen to memory T cells specific for vaccine immunity against Staphylococcus aureus","description":"Th17\u7d30\u80de\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e1\u7a2e\u3067\u3042\u308bIL-17\u3092\u7523\u751f\u3057\u7d30\u83cc\u611f\u67d3\u9632\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059T\u7d30\u80de\u3067\u3042\u308b\u3002\u4e00\u65b9\u3001\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u304c\u7523\u751f\u3059\u308b\u30b9\u30fc\u30d1\u30fc\u6297\u539f\u306fT\u7d30\u80de\u306e\u88dc\u52a9\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3057T\u7d30\u80de\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u80fd\u3092\u304b\u304f\u4e71\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u30b9\u30fc\u30d1\u30fc\u6297\u539f\u304c\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u30ef\u30af\u30c1\u30f3\u3067\u8a98\u5c0e\u3055\u308c\u305fTh17\u7d30\u80de\u306e\u88dc\u52a9\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3057\u3001IL-17\u7523\u751f\u80fd\u3092\u304b\u304f\u4e71\u3059\u308b\u65b0\u305f\u306a\u6bd2\u7d20\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u3092\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u3055\u3089\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3057\u305f\u30de\u30a6\u30b9\u306b\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u30b9\u30fc\u30d1\u30fc\u6297\u539f\u7523\u751f\u682a\u3001\u975e\u7523\u751f\u682a\u3092\u611f\u67d3\u3055\u305b\u30b9\u30fc\u30d1\u30fc\u6297\u539f\u304c\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c\u4e0e\u3048\u308b\u5f71\u97ff\u3068\u305d\u306e\u6a5f\u5e8f\u3092\u89e3\u660e\u3059\u308b\u3002","funder_award_id":"21K07000","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W4225372427","https://openalex.org/W4318542410","https://openalex.org/W4324311674","https://openalex.org/W4390696107","https://openalex.org/W4390947307","https://openalex.org/W4407032043","https://openalex.org/W4407094031"],"funded_outputs_count":7,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4160000.0,"currency":"JPY","amount_usd":37578.53,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (C)","start_date":"2021-04-01","end_date":"2025-03-31","start_year":2021,"end_year":2025,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K07000/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Kouji","family_name":"Narita","orcid":null,"role_start":null,"affiliation":{"name":"Hirosaki University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000030419220","type":"nrid","asserted_by":"kaken"}]}},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G7990360842","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"updated_date":"2026-10-16T03:01:01.000Z","created_date":"2026-07-13T04:17:19.000Z"}
