{"id":"https://openalex.org/G7253994112","display_name":"Tension-dependent regulation of alpha-catenin during morphogenesis in C. elegans","description":"Relevance Understanding how cells attach to one another is important for understanding many common birth defects, and how cancer cells lose their connections to one another and invade the body. This proposal examines a key protein, a-catenin, that regulates cell adhesiveness, and how this protein works together with a protein known as Tes to ensure that cells make proper connections in the body. By studying how these proteins work in living embryos, we will gain important information that serves as the backdrop for understanding and treating human disease.!","funder_award_id":"R01GM058038","funder":{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","doi":"10.13039/100000057"},"funded_outputs":["https://openalex.org/W28298447","https://openalex.org/W1990938297","https://openalex.org/W2000221061","https://openalex.org/W2004435774","https://openalex.org/W2013772670","https://openalex.org/W2023000417","https://openalex.org/W2025209845","https://openalex.org/W2028912069","https://openalex.org/W2031407476","https://openalex.org/W2038579587","https://openalex.org/W2040036679","https://openalex.org/W2048799860","https://openalex.org/W2054914758","https://openalex.org/W2068602123","https://openalex.org/W2073327767","https://openalex.org/W2080207847","https://openalex.org/W2093628441","https://openalex.org/W2095430101","https://openalex.org/W2096415418","https://openalex.org/W2097646823","https://openalex.org/W2109829581","https://openalex.org/W2110881251","https://openalex.org/W2113938305","https://openalex.org/W2115803302","https://openalex.org/W2121621688","https://openalex.org/W2123323139","https://openalex.org/W2123394940","https://openalex.org/W2128975512","https://openalex.org/W2130269585","https://openalex.org/W2131462081","https://openalex.org/W2142936127","https://openalex.org/W2144530087","https://openalex.org/W2145294610","https://openalex.org/W2149122365","https://openalex.org/W2149960350","https://openalex.org/W2152726106","https://openalex.org/W2154848589","https://openalex.org/W2155443081","https://openalex.org/W2167275854","https://openalex.org/W2171428849","https://openalex.org/W2185846714","https://openalex.org/W2188363350","https://openalex.org/W2210462916","https://openalex.org/W2242696863","https://openalex.org/W2260538622","https://openalex.org/W2285888671","https://openalex.org/W2289717558","https://openalex.org/W2341973829","https://openalex.org/W2344657213","https://openalex.org/W2410839914","https://openalex.org/W2551728568","https://openalex.org/W2602714350","https://openalex.org/W2748034654","https://openalex.org/W2761553324","https://openalex.org/W2765920731","https://openalex.org/W2951024242","https://openalex.org/W4211023214","https://openalex.org/W4232690806","https://openalex.org/W4241961325","https://openalex.org/W4296787143","https://openalex.org/W4309195580","https://openalex.org/W4323031725","https://openalex.org/W4380538692","https://openalex.org/W4402262136"],"funded_outputs_count":64,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":null,"currency":"USD","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"R01","start_date":"1998-08-01","end_date":"2023-02-28","start_year":1998,"end_year":2023,"landing_page_url":"https://reporter.nih.gov/project-details/7808905","doi":null,"provenance":"nih_exporter","lead_investigator":{"given_name":"JEFFREY D","family_name":"HARDIN","orcid":null,"role_start":null,"affiliation":{"name":"UNIVERSITY OF WISCONSIN-MADISON","country":"UNITED STATES","ids":null},"author":{"id":"https://openalex.org/A5088311127","display_name":"Jeff D. Hardin","orcid":"https://orcid.org/0000-0001-7399-6580"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G7253994112","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"updated_date":"2026-11-11T03:01:08.000Z","created_date":"2026-10-09T19:56:01.000Z"}