{"id":"https://openalex.org/G7171908392","display_name":"Systems biology of AKT signaling","description":"In cellular signal transduction, information in an external stimulus is coded as temporal patterns of signaling activities; however, the temporal coding mechanism has been poorly investigated. In this study, we modeled the epidermal growth factor (EGF)-dependent Akt pathway in PC12 cells based on experimental results, and found how the Akt pathway, which is involved in cell growth, specifically transfers temporal information of upstream signals to downstream. In addition, we theoretically analyzed a simple biochemical reaction and found that signal transfer efficiency of transient peak amplitude attenuates depending on the strength of negative regulation, and found that cells can control downstream sensitivity through attenuation of signal transfer efficiency by changing the expression level of negative regulators.","funder_award_id":"21240025","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"10.13039/501100001691"},"funded_outputs":["https://openalex.org/W1965435094","https://openalex.org/W1975444080","https://openalex.org/W1989761443","https://openalex.org/W2026992340","https://openalex.org/W2054357273","https://openalex.org/W2100901040","https://openalex.org/W2149182211","https://openalex.org/W7144337196"],"funded_outputs_count":8,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":32370000.0,"currency":"JPY","amount_usd":null,"amount_usd_basis":null,"recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Scientific Research (A)","start_date":null,"end_date":null,"start_year":null,"end_year":null,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21240025/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Shinya","family_name":"KURODA","orcid":null,"role_start":null,"affiliation":{"name":"The University of Tokyo","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000050273850","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5035549362","display_name":"Shinya Kuroda","orcid":"https://orcid.org/0000-0001-5059-8299"},"institutions":[]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G7171908392","primary_topic":null,"topics":null,"institution_awarded":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"updated_date":"2026-11-10T03:01:11.000Z","created_date":"2026-07-13T04:17:19.000Z"}