{"id":"https://openalex.org/G6861446459","display_name":"K\u00fc\u00e7\u00fck H\u00fccreli D\u0131\u015f\u0131 Akci\u011fer Kanseri Uyku Hali (Dormancy) Modelleri Olu\u015fturulmas\u0131 Ve Etiyopatogenezinin Omik Y\u00f6ntemlerle Ara\u015ft\u0131r\u0131lmas\u0131","description":"Akci\u011fer ve solunum yollar\u0131 kanserleri T\u00fcrkiye'de ve D\u00fcnya'da en s\u0131k g\u00f6r\u00fclen ve \u00f6l\u00fcmc\u00fcl kanser t\u00fcrleridir. K\u00fc\u00e7\u00fck h\u00fccreli d\u0131\u015f\u0131 akci\u011fer kanseri (KHDAK), akci\u011fer kanserlerinin % 85'ine kar\u015f\u0131l\u0131k gelmektedir ve yeni tan\u0131 alan hastalar\u0131n % 70'inde yerel olarak ilerlemi\u015f veya metastatik kanser bulundu\u011fu g\u00f6zlenmektedir. Metastazlar\u0131n \u00f6nemli bir k\u0131sm\u0131 y\u0131llar boyu sessiz kalabilme ve tedaviye diren\u00e7 g\u00f6sterme \u00f6zelli\u011fi olan mikrometastazlard\u0131r. Kemoterapi ve radyoterapi yakla\u015f\u0131mlar\u0131n\u0131n \u00e7o\u011fu b\u00f6l\u00fcnen h\u00fccreleri hedeflemektedir ve b\u00f6l\u00fcnmeyen ve uyku (dormancy) halindeki mikrometastazlar bu tedavilere diren\u00e7lidir. Uyku durumundaki h\u00fccreler hayattad\u0131r, senesense girmemi\u015ftir, fakat b\u00f6l\u00fcnmemektedir. Tam anla\u015f\u0131lamayan bir \u015fekilde, uyku durumundaki h\u00fccreler primer t\u00fcm\u00f6r olu\u015fumundan y\u0131llar sonra uyanabilmekte ve hastalarda yeniden t\u00fcm\u00f6r olu\u015fumuna neden olmaktad\u0131r (n\u00fcks). Kanserli h\u00fccrelerin uyku durumuna girmelerinin ard\u0131ndaki molek\u00fcler mekanizmalar meme kanseri dahil az say\u0131da kanser model al\u0131narak \u00e7al\u0131\u015f\u0131lm\u0131\u015ft\u0131r. \u0130lgin\u00e7tir ki, akci\u011fer kanserinin klinik \u00f6nemi ve g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131na ra\u011fmen literat\u00fcrde akci\u011fer kanseri h\u00fccrelerinin uyku durumu ile ilgili yeterli bilgi yoktur ve \u00e7ok az say\u0131da \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015ft\u0131r. Projemizde insan KHDAK uyku durumunun 3 boyutlu h\u00fccre k\u00fclt\u00fcr\u00fc y\u00f6ntemi ile in vitro h\u00fccresel modelleri olu\u015fturulmu\u015ftur. Bu modeller kullan\u0131larak yap\u0131lan omik analizler (transkriptomik, proteomik ve metabolomik) sayesinde uyku hali olu\u015fumu ile ba\u011flant\u0131l\u0131 yeni mRNA'lar, mikroRNA'lar, proteinler ve metabolitler ke\u015ffedilmi\u015ftir. Uyku ba\u011flant\u0131l\u0131 bu yeni gen ve proteinlerin ifadesi, insan KHDAK primer t\u00fcm\u00f6r ve mikrometastaz serilerinde, bilinen kanser ve uyku durumu belirte\u00e7leri ile kar\u015f\u0131la\u015ft\u0131r\u0131larak incelenmi\u015ftir. Doku setlerinde de umut var sonu\u00e7 elde edilen baz\u0131 yeni proteinlere kar\u015f\u0131 ila\u00e7 taramalar\u0131 da yap\u0131lm\u0131\u015f ve aday ila\u00e7lar\u0131n 2 ve 3 boyutlu h\u00fccre k\u00fclt\u00fcr\u00fc modellerinde kanser ve uyku haline kar\u015f\u0131 etkileri g\u00f6sterilmi\u015ftir. T\u00dcB\u0130TAK 1003, 216S489 kodlu proje kapsam\u0131nda 1 derleme ve 1 ara\u015ft\u0131rma makalesi bas\u0131lm\u0131\u015f ve bir\u00e7ok konferansta bildiri sunumlar\u0131 yap\u0131lm\u0131\u015ft\u0131r. Ayr\u0131ca en az 3 \u00f6zg\u00fcn ara\u015ft\u0131rma makalesi ve bir kitap b\u00f6l\u00fcm\u00fc haz\u0131rlanma a\u015famas\u0131ndad\u0131r. Ek olarak proje, 5 y\u00fcksek lisans, 3 doktora ve 1 doktora sonras\u0131 ara\u015ft\u0131rmac\u0131n\u0131n yeti\u015ftirilmesine de katk\u0131da bulunmu\u015ftur.","funder_award_id":"216S489","funder":{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma 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