{"id":"https://openalex.org/G6806996462","display_name":"Establishment of the new strategy for accurate diagnosis of zinc deficiency","description":"In general, zinc deficiency is diagnosed by evaluation of serum zinc status. However, serum zinc status is altered by daily fluctuation or during inflammation, which may be a problem in the case that the accurate diagnosis is required for elderly people because they often suffer from various chronic diseases. Because, at present, Japan faces super-aged society at present, establishing the new strategy for accurate diagnosis of zinc deficiency is more important than ever.In this study, I tried to establish such strategy by generating useful monoclonal antibody to detect proteins/enzymes whose expression is changed in response to zinc status. Moreover, I investigated zinc requiring enzyme activity whose activity was changed during zinc deficiency. I generated one antibody, which nicely detects zinc transporter in zinc-deficient dependent pattern, and one enzyme whose activity shows drastic change in response to zinc deficiency.","funder_award_id":"26660086","funder":{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","doi":"https://doi.org/10.13039/501100001691"},"funded_outputs":["https://openalex.org/W1428822444","https://openalex.org/W1498241693","https://openalex.org/W1978153351","https://openalex.org/W1987231329","https://openalex.org/W2056861165","https://openalex.org/W2161764351","https://openalex.org/W2305841752","https://openalex.org/W2373868424","https://openalex.org/W2565559032"],"funded_outputs_count":9,"parent_awards":[],"sub_awards":[],"sub_awards_count":0,"amount":4030000.0,"currency":"JPY","amount_usd":38990.88,"amount_usd_basis":"daily_rate","recipients":[],"recipient_countries":[],"recipient_regions":[],"research_scope":{"is_research":true,"basis":"funder_default","tier":1},"funding_type":"research","funder_scheme":"Grant-in-Aid for Challenging Exploratory Research","start_date":"2014-04-01","end_date":"2016-03-31","start_year":2014,"end_year":2016,"landing_page_url":"https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26660086/","doi":null,"provenance":"kaken","lead_investigator":{"given_name":"Kambe","family_name":"Taiho","orcid":null,"role_start":null,"affiliation":{"name":"Kyoto University","country":"Japan","ids":[{"id":"https://nrid.nii.ac.jp/nrid/1000090303875","type":"nrid","asserted_by":"kaken"}]},"author":{"id":"https://openalex.org/A5076876397","display_name":"Taiho Kambe","orcid":"https://orcid.org/0000-0001-9757-063X"},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}]},"co_lead_investigator":null,"investigators":null,"works_api_url":"https://api.openalex.org/works?filter=awards.id:G6806996462","primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-deficiency","display_name":"zinc deficiency","score":0.993},{"id":"https://openalex.org/keywords/zinc-status-assessment","display_name":"zinc status assessment","score":0.604},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.772},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.867},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.889},{"id":"https://openalex.org/keywords/zinc-transporters","display_name":"zinc transporters","score":0.884},{"id":"https://openalex.org/keywords/zinc-enzymes","display_name":"zinc metalloenzyme","score":0.775},{"id":"https://openalex.org/keywords/super-aged-society","display_name":"super-aged society","score":0.829}],"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8372,"display_name":"Good health and well-being"}],"institution_awarded":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"updated_date":"2026-11-13T03:01:57.000Z","created_date":"2026-07-13T04:17:19.000Z"}